Does Citrulline Blood Pressure Randomized Trial work?

The current Migaku evidence database contains 2 reusable source documents for Citrulline Blood Pressure Randomized Trial. This answer focuses on strength of evidence and what the studies can or cannot prove. - The primary objective of this systematic review and meta-analysis is to investigate whether L-citrulline supplementation can counteract the adverse effects of cold environments on individual blood pressure (BP), providing scientific evidence for the clinical development and application of L-citrulline as a cardiovascular protective nutritional supplement. [Luo P (2026); evidence level 1] - The Cochrane Risk of Bias tool and JADAD scoring scale were used to assess risk of bias and literature quality of the included randomized controlled trials (RCTs). [Luo P (2026); evidence level 1] - Results indicate that L-citrulline intake significantly reduced cold-induced SBP (-9.28 mmHg [95% CI: -10.66 to -7.90], p p = 0.01). [Luo P (2026); evidence level 1] - A comprehensive search was conducted across four electronic databases: PubMed, Cochrane Library, Embase, and Web of Science. [Luo P (2026); evidence level 1] - Background Postmenopausal women are at increased risk of developing cardiovascular, muscular, and metabolic dysfunction due to hormonal changes associated with aging. [Bahari H (2026); evidence level 1] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.