topicArtichoke Leaf Blood Pressure Randomized Trial
claimIt is widely promoted for weight management, reduction in risk factors for developing common chronic diseases, and longevity support [,,].
evidence level3
citationSzlapinski Sandra K. (2026)
sourceDecoding the Longevity Networks of the Mediterranean Diet: Systems Biology and Multi-Pathway Mechanisms Shaping Healthspan
topicArtichoke Leaf Blood Pressure Randomized Trial
claimTherefore, this review will discuss some of the available evidence for select polyphenols in the MD.
evidence level3
citationSzlapinski Sandra K. (2026)
sourceDecoding the Longevity Networks of the Mediterranean Diet: Systems Biology and Multi-Pathway Mechanisms Shaping Healthspan
topicArtichoke Leaf Blood Pressure Randomized Trial
claimWhile cost and access can be significant barriers to maintaining the MD lifestyle year-round, a complex formulation incorporating select, powerful constituents of the MD in dietary supplement capsule form allows for greater compliance and reduced variability during investigation of these polyphenols in preclinical and clinical protocol designs.
evidence level3
citationSzlapinski Sandra K. (2026)
sourceDecoding the Longevity Networks of the Mediterranean Diet: Systems Biology and Multi-Pathway Mechanisms Shaping Healthspan
topicArtichoke Leaf Blood Pressure Randomized Trial
claim1 2 3 2 4 5 The Mediterranean Diet (MD), long practiced in cultures around the Mediterranean Sea, is one of the most well-recognized and copied health-promoting dietary patterns.
evidence level3
citationSzlapinski Sandra K. (2026)
sourceDecoding the Longevity Networks of the Mediterranean Diet: Systems Biology and Multi-Pathway Mechanisms Shaping Healthspan
topicArtichoke Leaf Blood Pressure Randomized Trial
claimLow-density lipoprotein cholesterol (LDL-C) increases cardiovascular risk, whereas high-density lipoprotein cholesterol (HDL-C) decreases it [].
evidence level4
citationVitulano Nicola (2025)
sourceEffects of Novel Nutraceutical Combination on Lipid Pattern of Subjects with Sub-Optimal Blood Cholesterol Levels
topicArtichoke Leaf Blood Pressure Randomized Trial
claimClinical evidence supports the effectiveness of lowering LDL-C to prevent cardiovascular events.
evidence level4
citationVitulano Nicola (2025)
sourceEffects of Novel Nutraceutical Combination on Lipid Pattern of Subjects with Sub-Optimal Blood Cholesterol Levels
topicArtichoke Leaf Blood Pressure Randomized Trial
claimStudies show that LDL-C is both a high-risk marker and a direct cause of cardiovascular disease [].
evidence level4
citationVitulano Nicola (2025)
sourceEffects of Novel Nutraceutical Combination on Lipid Pattern of Subjects with Sub-Optimal Blood Cholesterol Levels
topicArtichoke Leaf Blood Pressure Randomized Trial
claim1 2 3 3 4 3 4 3 5 6 7 Cardiovascular diseases account for 32% of global deaths [].
evidence level4
citationVitulano Nicola (2025)
sourceEffects of Novel Nutraceutical Combination on Lipid Pattern of Subjects with Sub-Optimal Blood Cholesterol Levels