Quick Answer
Astragalus Immune Function Randomized Trial has evidence relevant to strength of evidence and what the studies can or cannot prove, but conclusions should stay close to the cited sources. One representative finding is: However, despite the increasing number of studies, current evidence on YPFS remains fragmented and lacks systematic integration.
Key Takeaways
- 01However, despite the increasing number of studies, current evidence on YPFS remains fragmented and lacks systematic integration. [Gao Shiyu (2026)]
- 02Further research by Huand Zhaosuggests that YPFS may influence biological processes, including tumor-associated angiogenesis and cell proliferation, by modulating multiple signaling pathways such as AGE-RAGE, IL-17, TNF, and MAPK. [Gao Shiyu (2026)]
- 03Compared with individual herbs, YPFS demonstrates superior efficacy in modulating Th1/Th2 and Th17/Treg balance, improving tumor-associated immunosuppressive microenvironments (eg., PD-1/PD-L1 and STAT3 signaling axes), and enhancing anti-infective capacity. [Gao Shiyu (2026)]
- 041 2 3 4 5 6–8 http://mpns.kew.org/ http://mpns.kew.org/ http://mpns.kew.org/ Dan xi Xin Fa Yupingfeng San (YPFS) is a classical traditional Chinese herbal formula (TCM prescription),composed of Astragalus mongholicus Bunge (Huang Qi) (January 22, 2026), Atractylodes macrocephala Koidz. [Gao Shiyu (2026)]
The current Migaku evidence database contains 2 reusable source documents for Astragalus Immune Function Randomized Trial. This answer focuses on strength of evidence and what the studies can or cannot prove.
- However, despite the increasing number of studies, current evidence on YPFS remains fragmented and lacks systematic integration. [Gao Shiyu (2026); evidence level 3]
- Further research by Huand Zhaosuggests that YPFS may influence biological processes, including tumor-associated angiogenesis and cell proliferation, by modulating multiple signaling pathways such as AGE-RAGE, IL-17, TNF, and MAPK. [Gao Shiyu (2026); evidence level 3]
- Compared with individual herbs, YPFS demonstrates superior efficacy in modulating Th1/Th2 and Th17/Treg balance, improving tumor-associated immunosuppressive microenvironments (eg., PD-1/PD-L1 and STAT3 signaling axes), and enhancing anti-infective capacity. [Gao Shiyu (2026); evidence level 3]
- 1 2 3 4 5 6–8 http://mpns.kew.org/ http://mpns.kew.org/ http://mpns.kew.org/ Dan xi Xin Fa Yupingfeng San (YPFS) is a classical traditional Chinese herbal formula (TCM prescription),composed of Astragalus mongholicus Bunge (Huang Qi) (January 22, 2026), Atractylodes macrocephala Koidz. [Gao Shiyu (2026); evidence level 3]
- 5 6 7 8 9 Aging is accompanied by a progressive decline in cellular and organ function, leading to an increased incidence of chronic diseases and neurodegenerative disorders. [Kanubaddi Kiran Reddy (2026); evidence level 4]
Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording.
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Sources