Does Alpha Gpc Power Performance Randomized Trial work?

Updated October 2026

Quick Answer

Alpha Gpc Power Performance Randomized Trial has evidence relevant to strength of evidence and what the studies can or cannot prove, but conclusions should stay close to the cited sources. One representative finding is: Background Nutrition plays a key role in training and athletic performance and dietary supplements can make a small, but potentially valuable, contribution to achieving peak athletic performance.

Key Takeaways

  • 01Background Nutrition plays a key role in training and athletic performance and dietary supplements can make a small, but potentially valuable, contribution to achieving peak athletic performance. [Harrington RN (2023)]
  • 02This study is the first to investigate the effects of supplementation from the combination of BCAAs, L-citrulline, and A-GPC on exercise performance. [Harrington RN (2023)]
  • 03Serum free choline was found to be elevated in the two A-GPC groups as compared to placebo (132% and 59% respectively). [Marcus L (2017)]
  • 04Serum TSH was found to be significantly depressed in the 500 mg A-GPC group compared to other treatments ( p p Conclusions Based upon this evidence, and previous evidence regarding A-GPC, it should be considered as an emerging ergogenic supplement. [Marcus L (2017)]
The current Migaku evidence database contains 2 reusable source documents for Alpha Gpc Power Performance Randomized Trial. This answer focuses on strength of evidence and what the studies can or cannot prove. - Background Nutrition plays a key role in training and athletic performance and dietary supplements can make a small, but potentially valuable, contribution to achieving peak athletic performance. [Harrington RN (2023); evidence level 2] - This study is the first to investigate the effects of supplementation from the combination of BCAAs, L-citrulline, and A-GPC on exercise performance. [Harrington RN (2023); evidence level 2] - Serum free choline was found to be elevated in the two A-GPC groups as compared to placebo (132% and 59% respectively). [Marcus L (2017); evidence level 4] - Serum TSH was found to be significantly depressed in the 500 mg A-GPC group compared to other treatments ( p p Conclusions Based upon this evidence, and previous evidence regarding A-GPC, it should be considered as an emerging ergogenic supplement. [Marcus L (2017); evidence level 4] - Background Recent studies have suggested that alpha glycerylphosphorylcholine (A-GPC) may be an effective ergogenic aid. [Marcus L (2017); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

Sources

  1. Effects of branched chain amino acids, l-citrulline, and alpha-glycerylphosphorylcholine supplementation on exercise performance in trained cyclists: a randomized crossover trial.
  2. Evaluation of the effects of two doses of alpha glycerylphosphorylcholine on physical and psychomotor performance.