topicUrolithin A Muscle Function Randomized Trial
claimThis review summarizes current evidence on nutritional compounds that target aging-related pathways, focusing on interventions that influence mitochondrial health, cognitive performance, immune function, metabolic regulation, and maintenance of muscle mass in older adults.
evidence level4
citationKurtz JA (2026)
sourceTargeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits.
topicUrolithin A Muscle Function Randomized Trial
claimRecent findings Evidence indicates that several targeted nutrients, including protein, probiotics, antioxidants, and emerging mitochondrial-support compounds, may contribute to healthy aging.
evidence level4
citationKurtz JA (2026)
sourceTargeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits.
topicUrolithin A Muscle Function Randomized Trial
claimA personalized, evidence-informed supplementation strategy integrated with exercise and balanced nutrition may help optimize physiological function in aging adults.
evidence level4
citationKurtz JA (2026)
sourceTargeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits.
topicUrolithin A Muscle Function Randomized Trial
claimPurpose of review Aging is marked by progressive physiological decline driven by chronic inflammation, mitochondrial dysfunction, and impaired metabolic and musculoskeletal resilience.
evidence level4
citationKurtz JA (2026)
sourceTargeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits.
topicUrolithin A Muscle Function Randomized Trial
claimIn particular, identification of certain exogenous medications, supplements, or even foods that can crystallize in the urinary tract is critical, so that exposure can be reduced and stones prevented.
evidence level4
citationBest Sara L. (2026)
sourceFirst Reported Human Cases of Urolithin A Renal Calculi
topicUrolithin A Muscle Function Randomized Trial
claimThe compound urolithin A (ULA) was first described in 1964 as a component of “clover stones” in sheep.Found during necropsy, this material filled the urinary tracts of the afflicted flock that died of obstructive renal failure.
evidence level4
citationBest Sara L. (2026)
sourceFirst Reported Human Cases of Urolithin A Renal Calculi
topicUrolithin A Muscle Function Randomized Trial
claimThe work involved analysis of kidney stone specimens with limited associated, nonidentifiable information; therefore, the study met criteria for exemption under the US Federal Policy for the Protection of Human Subjects (45 CFR 46.104(d)).
evidence level4
citationBest Sara L. (2026)
sourceFirst Reported Human Cases of Urolithin A Renal Calculi
topicUrolithin A Muscle Function Randomized Trial
claimUrolithiasis is common, afflicting approximately 14% of the American population at least once during their lifetime.
evidence level4
citationBest Sara L. (2026)
sourceFirst Reported Human Cases of Urolithin A Renal Calculi