Structured evidence table for Urolithin A Exercise Performance Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Urolithin A Exercise Performance Randomized Trial | Individuals with sarcopenia face a significantly elevated risk of falls, fractures, cognitive impairment, and functional dependency, leading to increased hospitalization rates, prolonged lengths of stay, and greater healthcare costs [,,]. | 4 | Chin Hui San (2026) | Molecular Mechanisms and Nutritional Modulation in Sarcopenia: A Narrative Review |
| Urolithin A Exercise Performance Randomized Trial | These disruptions converge on key processes such as reduced neuromuscular integrity, impaired energy metabolism, and blunted anabolic signaling, ultimately contributing to declines in muscle strength and function. | 4 | Chin Hui San (2026) | Molecular Mechanisms and Nutritional Modulation in Sarcopenia: A Narrative Review |
| Urolithin A Exercise Performance Randomized Trial | As a narrative synthesis, formal systematic review methodology and risk-of-bias assessment, were not applied. | 4 | Chin Hui San (2026) | Molecular Mechanisms and Nutritional Modulation in Sarcopenia: A Narrative Review |
| Urolithin A Exercise Performance Randomized Trial | 1 2 3 4 5 6 7 3 Sarcopenia, defined as the progressive loss of skeletal muscle mass and function, is widely acknowledged as a critical determinant of health outcomes in aging populations and patients with chronic disease. | 4 | Chin Hui San (2026) | Molecular Mechanisms and Nutritional Modulation in Sarcopenia: A Narrative Review |
| Urolithin A Exercise Performance Randomized Trial | Proteomic screening of skeletal muscle biopsies revealed UA upregulated pathways associated with mitochondria, while downregulating inflammatory pathways. | 4 | Whitfield J (2025) | Evaluating the Impact of Urolithin A Supplementation on Running Performance, Recovery, and Mitochondrial Biomarkers in Highly Trained Male Distance Runners. |
| Urolithin A Exercise Performance Randomized Trial | While not statistically significant, UA led to a medium effect for increased markers of mitophagy (d = - 0.74), without changes in mitochondrial function. | 4 | Whitfield J (2025) | Evaluating the Impact of Urolithin A Supplementation on Running Performance, Recovery, and Mitochondrial Biomarkers in Highly Trained Male Distance Runners. |
| Urolithin A Exercise Performance Randomized Trial | However, despite a reduction in rating of exertion and increased aerobic capacity, UA supplementation did not further enhance performance in highly trained male endurance athletes. | 4 | Whitfield J (2025) | Evaluating the Impact of Urolithin A Supplementation on Running Performance, Recovery, and Mitochondrial Biomarkers in Highly Trained Male Distance Runners. |
| Urolithin A Exercise Performance Randomized Trial | Background Urolithin A (UA) is a metabolite produced by gut bacteria following the consumption of ellagitannin-rich foods. | 4 | Whitfield J (2025) | Evaluating the Impact of Urolithin A Supplementation on Running Performance, Recovery, and Mitochondrial Biomarkers in Highly Trained Male Distance Runners. |
Source documents