supplement evidence

Ubiquinol Fatigue Randomized Trial Evidence Table

Structured evidence table for Ubiquinol Fatigue Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Ubiquinol Fatigue Randomized TrialConclusions Supplementation with ubiquinone, ubiquinol, and ubiquinol + GG was well-tolerated and increased CoQ10 concentrations among healthy adults.2D'Adamo CR (2026)A Randomized, Double-Blind, Placebo-Controlled Trial Comparing the Effects of Commercially Available Ubiquinone, Ubiquinol, and Geranylgeraniol Dietary Supplements on Plasma CoQ10 Concentrations.
Ubiquinol Fatigue Randomized TrialBackground Coenzyme Q10 (CoQ10) plays a fundamental role in energy production and antioxidant activity in humans.2D'Adamo CR (2026)A Randomized, Double-Blind, Placebo-Controlled Trial Comparing the Effects of Commercially Available Ubiquinone, Ubiquinol, and Geranylgeraniol Dietary Supplements on Plasma CoQ10 Concentrations.
Ubiquinol Fatigue Randomized TrialDirect supplementation with both the ubiquinol and ubiquinone forms of CoQ10 increases circulating concentrations, although comparative efficacy remains uncertain.2D'Adamo CR (2026)A Randomized, Double-Blind, Placebo-Controlled Trial Comparing the Effects of Commercially Available Ubiquinone, Ubiquinol, and Geranylgeraniol Dietary Supplements on Plasma CoQ10 Concentrations.
Ubiquinol Fatigue Randomized TrialDietary supplementation with ubiquinol, the reduced form of the antioxidant and cellular energizer CoQ10, may support cognitive function in older individuals.2Nankivell MC (2026)Effect of Ubiquinol on Cognitive Function, Blood Pressure, Arterial Stiffness, and Biomarkers of Oxidative Stress and Inflammation in the Elderly: A Randomized Trial.
Ubiquinol Fatigue Randomized TrialWe found that ubiquinol supplementation did not facilitate group differences (controlling for baseline values and relevant demographics) in cognitive function, blood biomarkers reflective of oxidative stress or inflammation, measures of cardiovascular health, or subjective mood at study end.2Nankivell MC (2026)Effect of Ubiquinol on Cognitive Function, Blood Pressure, Arterial Stiffness, and Biomarkers of Oxidative Stress and Inflammation in the Elderly: A Randomized Trial.
Ubiquinol Fatigue Randomized TrialWe conclude that adequately powered future clinical trials should examine whether long-term supplementation with ubiquinol can support cognitive function in older adults at risk of cognitive decline or with health conditions predisposing them to risk factors associated with decline.2Nankivell MC (2026)Effect of Ubiquinol on Cognitive Function, Blood Pressure, Arterial Stiffness, and Biomarkers of Oxidative Stress and Inflammation in the Elderly: A Randomized Trial.
Ubiquinol Fatigue Randomized TrialOlder age is typically characterized by decrements in cognitive performance relative to younger adults, though it may not necessarily reach clinical impairment.2Nankivell MC (2026)Effect of Ubiquinol on Cognitive Function, Blood Pressure, Arterial Stiffness, and Biomarkers of Oxidative Stress and Inflammation in the Elderly: A Randomized Trial.
topicUbiquinol Fatigue Randomized Trial
claimConclusions Supplementation with ubiquinone, ubiquinol, and ubiquinol + GG was well-tolerated and increased CoQ10 concentrations among healthy adults.
evidence level2
citationD'Adamo CR (2026)
sourceA Randomized, Double-Blind, Placebo-Controlled Trial Comparing the Effects of Commercially Available Ubiquinone, Ubiquinol, and Geranylgeraniol Dietary Supplements on Plasma CoQ10 Concentrations.
topicUbiquinol Fatigue Randomized Trial
claimBackground Coenzyme Q10 (CoQ10) plays a fundamental role in energy production and antioxidant activity in humans.
evidence level2
citationD'Adamo CR (2026)
sourceA Randomized, Double-Blind, Placebo-Controlled Trial Comparing the Effects of Commercially Available Ubiquinone, Ubiquinol, and Geranylgeraniol Dietary Supplements on Plasma CoQ10 Concentrations.
topicUbiquinol Fatigue Randomized Trial
claimDirect supplementation with both the ubiquinol and ubiquinone forms of CoQ10 increases circulating concentrations, although comparative efficacy remains uncertain.
evidence level2
citationD'Adamo CR (2026)
sourceA Randomized, Double-Blind, Placebo-Controlled Trial Comparing the Effects of Commercially Available Ubiquinone, Ubiquinol, and Geranylgeraniol Dietary Supplements on Plasma CoQ10 Concentrations.
topicUbiquinol Fatigue Randomized Trial
claimDietary supplementation with ubiquinol, the reduced form of the antioxidant and cellular energizer CoQ10, may support cognitive function in older individuals.
evidence level2
citationNankivell MC (2026)
sourceEffect of Ubiquinol on Cognitive Function, Blood Pressure, Arterial Stiffness, and Biomarkers of Oxidative Stress and Inflammation in the Elderly: A Randomized Trial.
topicUbiquinol Fatigue Randomized Trial
claimWe found that ubiquinol supplementation did not facilitate group differences (controlling for baseline values and relevant demographics) in cognitive function, blood biomarkers reflective of oxidative stress or inflammation, measures of cardiovascular health, or subjective mood at study end.
evidence level2
citationNankivell MC (2026)
sourceEffect of Ubiquinol on Cognitive Function, Blood Pressure, Arterial Stiffness, and Biomarkers of Oxidative Stress and Inflammation in the Elderly: A Randomized Trial.
topicUbiquinol Fatigue Randomized Trial
claimWe conclude that adequately powered future clinical trials should examine whether long-term supplementation with ubiquinol can support cognitive function in older adults at risk of cognitive decline or with health conditions predisposing them to risk factors associated with decline.
evidence level2
citationNankivell MC (2026)
sourceEffect of Ubiquinol on Cognitive Function, Blood Pressure, Arterial Stiffness, and Biomarkers of Oxidative Stress and Inflammation in the Elderly: A Randomized Trial.
topicUbiquinol Fatigue Randomized Trial
claimOlder age is typically characterized by decrements in cognitive performance relative to younger adults, though it may not necessarily reach clinical impairment.
evidence level2
citationNankivell MC (2026)
sourceEffect of Ubiquinol on Cognitive Function, Blood Pressure, Arterial Stiffness, and Biomarkers of Oxidative Stress and Inflammation in the Elderly: A Randomized Trial.

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Source documents

  1. A Randomized, Double-Blind, Placebo-Controlled Trial Comparing the Effects of Commercially Available Ubiquinone, Ubiquinol, and Geranylgeraniol Dietary Supplements on Plasma CoQ10 Concentrations.
  2. Effect of Ubiquinol on Cognitive Function, Blood Pressure, Arterial Stiffness, and Biomarkers of Oxidative Stress and Inflammation in the Elderly: A Randomized Trial.