sleep

Tryptophan Sleep Systematic Review Evidence Table

Structured evidence table for Tryptophan Sleep Systematic Review, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Tryptophan Sleep Systematic ReviewCurrent pharmacological management, including benzodiazepine receptor agonists [], melatonin-based preparations [], and antihistaminergic agents [], is limited by tolerance, dependence risk, and rebound sleep disturbance upon withdrawal.4Liang Lili (2026)Bifidobacterium longum B18 Modulates Pharmacologically Induced Sleep Parameters in Rats in Association with Altered Tryptophan–Melatonin Metabolism
Tryptophan Sleep Systematic ReviewIn other experimental contexts, specific[] and[] strains have been associated with reduced IDO-related kynurenine pathway activity, suggesting a potential role in preserving Trp availability.4Liang Lili (2026)Bifidobacterium longum B18 Modulates Pharmacologically Induced Sleep Parameters in Rats in Association with Altered Tryptophan–Melatonin Metabolism
Tryptophan Sleep Systematic ReviewInflammatory conditions have been proposed to modulate IDO1-related tryptophan metabolism and kynurenine pathway activity [,]; however, direct mechanistic evidence linking inflammation-induced IDO1 upregulation to altered Trp flux remains limited and warrants further investigation.4Liang Lili (2026)Bifidobacterium longum B18 Modulates Pharmacologically Induced Sleep Parameters in Rats in Association with Altered Tryptophan–Melatonin Metabolism
Tryptophan Sleep Systematic Review1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 Sleep, which occupies approximately one-third of the human lifespan, plays indispensable roles in neural homeostasis and synaptic plasticity [], metabolic homeostasis [,], and immune regulation [], and its disruption has been linked to impaired cognition [,], emotional dysregulation [,,], and metabolic disorders [,].4Liang Lili (2026)Bifidobacterium longum B18 Modulates Pharmacologically Induced Sleep Parameters in Rats in Association with Altered Tryptophan–Melatonin Metabolism
Tryptophan Sleep Systematic ReviewTryptophan–Serotonin–Melatonin Pathway and It Contribution to Mood and Cognitive Changes During Sleep Deprivation?4Sochal M (2026)Tryptophan–Serotonin–Melatonin Pathway and It Contribution to Mood and Cognitive Changes During Sleep Deprivation?
topicTryptophan Sleep Systematic Review
claimCurrent pharmacological management, including benzodiazepine receptor agonists [], melatonin-based preparations [], and antihistaminergic agents [], is limited by tolerance, dependence risk, and rebound sleep disturbance upon withdrawal.
evidence level4
citationLiang Lili (2026)
sourceBifidobacterium longum B18 Modulates Pharmacologically Induced Sleep Parameters in Rats in Association with Altered Tryptophan–Melatonin Metabolism
topicTryptophan Sleep Systematic Review
claimIn other experimental contexts, specific[] and[] strains have been associated with reduced IDO-related kynurenine pathway activity, suggesting a potential role in preserving Trp availability.
evidence level4
citationLiang Lili (2026)
sourceBifidobacterium longum B18 Modulates Pharmacologically Induced Sleep Parameters in Rats in Association with Altered Tryptophan–Melatonin Metabolism
topicTryptophan Sleep Systematic Review
claimInflammatory conditions have been proposed to modulate IDO1-related tryptophan metabolism and kynurenine pathway activity [,]; however, direct mechanistic evidence linking inflammation-induced IDO1 upregulation to altered Trp flux remains limited and warrants further investigation.
evidence level4
citationLiang Lili (2026)
sourceBifidobacterium longum B18 Modulates Pharmacologically Induced Sleep Parameters in Rats in Association with Altered Tryptophan–Melatonin Metabolism
topicTryptophan Sleep Systematic Review
claim1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 Sleep, which occupies approximately one-third of the human lifespan, plays indispensable roles in neural homeostasis and synaptic plasticity [], metabolic homeostasis [,], and immune regulation [], and its disruption has been linked to impaired cognition [,], emotional dysregulation [,,], and metabolic disorders [,].
evidence level4
citationLiang Lili (2026)
sourceBifidobacterium longum B18 Modulates Pharmacologically Induced Sleep Parameters in Rats in Association with Altered Tryptophan–Melatonin Metabolism
topicTryptophan Sleep Systematic Review
claimTryptophan–Serotonin–Melatonin Pathway and It Contribution to Mood and Cognitive Changes During Sleep Deprivation?
evidence level4
citationSochal M (2026)
sourceTryptophan–Serotonin–Melatonin Pathway and It Contribution to Mood and Cognitive Changes During Sleep Deprivation?

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Source documents

  1. Bifidobacterium longum B18 Modulates Pharmacologically Induced Sleep Parameters in Rats in Association with Altered Tryptophan–Melatonin Metabolism
  2. Tryptophan–Serotonin–Melatonin Pathway and It Contribution to Mood and Cognitive Changes During Sleep Deprivation?