Structured evidence table for Tryptophan Sleep Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Tryptophan Sleep Randomized Trial | Increasing evidence suggests that CFS involves not only peripheral metabolic and gastrointestinal abnormalities but also central nervous system dysfunction. | 2 | Jin M (2026) | Tuina for chronic fatigue syndrome: study protocol for a randomized controlled trial integrating tryptophan metabolism, gut microbiota, and brain network alterations. |
| Tryptophan Sleep Randomized Trial | Background Chronic fatigue syndrome (CFS) is a disabling multisystem disorder characterized by persistent fatigue, post-exertional malaise, unrefreshing sleep, and neurocognitive and gastrointestinal symptoms. | 2 | Jin M (2026) | Tuina for chronic fatigue syndrome: study protocol for a randomized controlled trial integrating tryptophan metabolism, gut microbiota, and brain network alterations. |
| Tryptophan Sleep Randomized Trial | High-altitude-specific evidence for both behavioral and pharmacological treatments therefore remains limited. | 3 | Yang Huaxiucairang (2026) | Hypoxia-Induced Gut-Brain Axis Remodeling and Insomnia: Mechanisms and Microbiota Adaptive Regulation from a Translational Perspective |
| Tryptophan Sleep Randomized Trial | 26–28 29–31 32 Against this neuroendocrine background, microbiota-derived signals may influence sleep and CNS function through metabolic, immune, and neural mechanisms.Human observational studies have reported differences in gut microbial composition, metabolic function, and microbiota-associated inflammatory profiles between individuals with insomnia and healthy controls. | 3 | Yang Huaxiucairang (2026) | Hypoxia-Induced Gut-Brain Axis Remodeling and Insomnia: Mechanisms and Microbiota Adaptive Regulation from a Translational Perspective |
| Tryptophan Sleep Randomized Trial | Hence, this review consolidates current evidence on how HA hypoxia remodels the GBA to trigger or worsen insomnia, identifies translational obstacles, evaluates emerging intervention strategies, and outlines a research roadmap for microbiota-focused approaches in low-oxygen populations. | 3 | Yang Huaxiucairang (2026) | Hypoxia-Induced Gut-Brain Axis Remodeling and Insomnia: Mechanisms and Microbiota Adaptive Regulation from a Translational Perspective |
| Tryptophan Sleep Randomized Trial | 1 2–4 5 6 7 8 9 10 11 12 High-altitude (HA) environments, typically defined as elevations exceeding 2500 meters, present significant physiological challenges to the human body due to hypobaric hypoxia. | 3 | Yang Huaxiucairang (2026) | Hypoxia-Induced Gut-Brain Axis Remodeling and Insomnia: Mechanisms and Microbiota Adaptive Regulation from a Translational Perspective |
Source documents