topicTocotrienols Lipid Profile Meta-Analysis
claimSOD activity was decreased after 3 (p Conclusion The observed improvement of plasma cholesterol, AGE and antioxidant vitamin levels as well as the reduced protein damage may indicate a restoration of redox balance after TRF supplementation, particularly in individuals over 50 years of age.
evidence level2
citationChin SF (2011)
sourceTocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study.
topicTocotrienols Lipid Profile Meta-Analysis
claimBackground Vitamin E supplements containing tocotrienols are now being recommended for optimum health but its effects are scarcely known.
evidence level2
citationChin SF (2011)
sourceTocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study.
topicTocotrienols Lipid Profile Meta-Analysis
claimThe objective was to determine the effects of Tocotrienol Rich Fraction (TRF) supplementation on lipid profile and oxidative status in healthy older individuals at a dose of 160 mg/day for 6 months.
evidence level2
citationChin SF (2011)
sourceTocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study.
topicTocotrienols Lipid Profile Meta-Analysis
claimIntroduction Sarcopenia, characterised by age-associated decline in skeletal muscle mass and function, is driven by multifactorial mechanisms including oxidative stress, chronic inflammation, and genomic instability.
evidence level4
citationSaud Gany SL (2026)
sourceCorrelation between oxidative stress and inflammation with metabolomics profile in skeletal muscle of ageing animal model and its modulation by tocotrienol-rich fraction.
topicTocotrienols Lipid Profile Meta-Analysis
claimHowever, in vivo evidence exploring TRF's multifaceted role in ageing muscle remains limited.
evidence level4
citationSaud Gany SL (2026)
sourceCorrelation between oxidative stress and inflammation with metabolomics profile in skeletal muscle of ageing animal model and its modulation by tocotrienol-rich fraction.
topicTocotrienols Lipid Profile Meta-Analysis
claimResults Ageing significantly increased oxidative damage, pro-inflammatory markers, and DNA fragmentation, while reducing antioxidant enzyme activities and disrupting metabolic profiles.
evidence level4
citationSaud Gany SL (2026)
sourceCorrelation between oxidative stress and inflammation with metabolomics profile in skeletal muscle of ageing animal model and its modulation by tocotrienol-rich fraction.
topicTocotrienols Lipid Profile Meta-Analysis
claimThe imbalance between reactive oxygen species (ROS) and antioxidant defence contributes to mitochondrial dysfunction and DNA damage, thereby affecting cellular metabolism and promoting muscle degeneration.
evidence level4
citationSaud Gany SL (2026)
sourceCorrelation between oxidative stress and inflammation with metabolomics profile in skeletal muscle of ageing animal model and its modulation by tocotrienol-rich fraction.