Structured evidence table for Tocotrienols Cognition Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Tocotrienols Cognition Randomized Trial | This research aims to investigate the efficacy of tocotrienol-rich fraction (TRF) on various health parameters associated with general well-being in individuals aged between 50 years and 75 years. | 2 | Amir Razak NAN (2025) | Effectiveness of Tocotrienol-Rich Fraction in Older Adults: Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial. |
| Tocotrienols Cognition Randomized Trial | Background Tocotrienol, a naturally occurring form of vitamin E, has been extensively studied for its potent antioxidant, anti-inflammatory, and immune-stimulating properties. | 2 | Amir Razak NAN (2025) | Effectiveness of Tocotrienol-Rich Fraction in Older Adults: Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial. |
| Tocotrienols Cognition Randomized Trial | However, the clinical impact of tocotrienol supplementation on older adults' overall health and well-being remains relatively unexplored. | 2 | Amir Razak NAN (2025) | Effectiveness of Tocotrienol-Rich Fraction in Older Adults: Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial. |
| Tocotrienols Cognition Randomized Trial | 1 2 3 4 5 6 In the general population, subjective memory complaints (SMC) are associated with a reduced global quality of life, increased risk of depression, and negative impact on daily living activities (,). | 2 | Lopresti Adrian L. (2025) | An examination into the effects of tocotrienols (TheraPrimE® rice) on cognitive abilities and sleep in healthy adults: a randomised, double-blind, placebo-controlled trial |
| Tocotrienols Cognition Randomized Trial | Research also suggests that SMC in middle age is a concern as it is associated with cortical thinning in brain regions affected by Alzheimer’s disease (AD) and poorer performance on objective memory tests (). | 2 | Lopresti Adrian L. (2025) | An examination into the effects of tocotrienols (TheraPrimE® rice) on cognitive abilities and sleep in healthy adults: a randomised, double-blind, placebo-controlled trial |
| Tocotrienols Cognition Randomized Trial | Memory complaints are distressing for adults of all ages and are associated with greater negative affect (,). | 2 | Lopresti Adrian L. (2025) | An examination into the effects of tocotrienols (TheraPrimE® rice) on cognitive abilities and sleep in healthy adults: a randomised, double-blind, placebo-controlled trial |
| Tocotrienols Cognition Randomized Trial | Older people with SMC are twice as likely to develop dementia compared to individuals without SMC. | 2 | Lopresti Adrian L. (2025) | An examination into the effects of tocotrienols (TheraPrimE® rice) on cognitive abilities and sleep in healthy adults: a randomised, double-blind, placebo-controlled trial |
Source documents