topicThiamine Fatigue Randomized Trial
claimSupplementation with B vitamins and magnesium improved fatigue and symptom-based disease activity scores in UC; however, effects on underlying inflammatory activity remain uncertain.
evidence level4
citationRamezani E (2026)
sourceEffects of B vitamins and magnesium on fatigue, disease activity and quality of life in inflammatory bowel disease.
topicThiamine Fatigue Randomized Trial
claimThis study investigated the efficacy of supplementation with B vitamins and magnesium in alleviating fatigue, improving disease activity, and health-related quality of life (HRQoL) in patients with inflammatory bowel disease (IBD) based on patient-reported outcomes.
evidence level4
citationRamezani E (2026)
sourceEffects of B vitamins and magnesium on fatigue, disease activity and quality of life in inflammatory bowel disease.
topicThiamine Fatigue Randomized Trial
claimIn this randomized, double-blind, placebo-controlled trial, 98 adults with IBD in remission were randomized (1:1) to receive daily supplementation with vitamins B 1 , B 6 , B 12 , and magnesium or a matching placebo for 4 weeks.
evidence level4
citationRamezani E (2026)
sourceEffects of B vitamins and magnesium on fatigue, disease activity and quality of life in inflammatory bowel disease.
topicThiamine Fatigue Randomized Trial
claimBackground In patients with Inflammatory Bowel Disease (IBD), fatigue is a debilitating problem and may be associated with sleep disturbance, anxiety, depression, anemia, use of systemic steroids and active phase of the disease.
evidence level4
citationMorais T (2026)
sourcePHARMACOLOGICAL TREATMENTS FOR FATIGUE IN INFLAMMATORY BOWEL DISEASE PATIENTS: AN INTEGRATIVE REVIEW.
topicThiamine Fatigue Randomized Trial
claimIn addition, fatigue also affects the working conditions of these patients, as it is associated with absenteeism and is a reason for time off work, surpassing medical appointments and abdominal pain.
evidence level4
citationMorais T (2026)
sourcePHARMACOLOGICAL TREATMENTS FOR FATIGUE IN INFLAMMATORY BOWEL DISEASE PATIENTS: AN INTEGRATIVE REVIEW.
topicThiamine Fatigue Randomized Trial
claimFatigue symptoms have been reduced with the use of vedolizumab, upadacitinib and modafinil.
evidence level4
citationMorais T (2026)
sourcePHARMACOLOGICAL TREATMENTS FOR FATIGUE IN INFLAMMATORY BOWEL DISEASE PATIENTS: AN INTEGRATIVE REVIEW.