Structured evidence table for Theacrine Focus Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Theacrine Focus Randomized Trial | The hallmark of PD is the degeneration of dopaminergic neurons in the substantia nigra, leading to reduced dopamine levels in the striatum (Bloem et al.). | 1 | Zhao Wanlin (2025) | Herbal Interventions in Parkinson’s Disease: A Systematic Review of Preclinical Studies |
| Theacrine Focus Randomized Trial | However, these therapies fail to address “the root cause” of PD and are associated with long-term side effects, including nausea, headaches, sleep disturbances, and drug-induced motor complications (Li et al.). | 1 | Zhao Wanlin (2025) | Herbal Interventions in Parkinson’s Disease: A Systematic Review of Preclinical Studies |
| Theacrine Focus Randomized Trial | Numerous herbal candidates for PD treatment have advanced to clinical trials (Prasad and Hung), with evidence indicating that TCM can significantly alleviate symptoms, improve patients’ quality of life and maintain a favorable safety profile. | 1 | Zhao Wanlin (2025) | Herbal Interventions in Parkinson’s Disease: A Systematic Review of Preclinical Studies |
| Theacrine Focus Randomized Trial | 2021 2021 2020 Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease, with its incidence rising faster than any other neurological condition. | 1 | Zhao Wanlin (2025) | Herbal Interventions in Parkinson’s Disease: A Systematic Review of Preclinical Studies |
| Theacrine Focus Randomized Trial | Caffeine increased MAOD ( p 2 and THb slopes were not significantly affected in any condition, suggesting that performance gains were mediated by mechanisms other than local oxygen delivery. | 4 | Jovanov P (2025) | Theacrine as a novel ergogenic aid: impact on canoe sprint performance. |
| Theacrine Focus Randomized Trial | Conclusion Caffeine remains a powerful ergogenic aid in sprint paddling, enhancing both mechanical output and muscle oxygen utilization. | 4 | Jovanov P (2025) | Theacrine as a novel ergogenic aid: impact on canoe sprint performance. |
| Theacrine Focus Randomized Trial | Background Caffeine is a popular ergogenic aid in high-intensity sports, but it can cause side effects like cardiovascular stress and tolerance buildup. | 4 | Jovanov P (2025) | Theacrine as a novel ergogenic aid: impact on canoe sprint performance. |
| Theacrine Focus Randomized Trial | Theacrine, a structurally similar purine alkaloid, may offer comparable performance benefits with fewer adverse effects. | 4 | Jovanov P (2025) | Theacrine as a novel ergogenic aid: impact on canoe sprint performance. |
Source documents