Structured evidence table for Taurine Cognition Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Taurine Cognition Randomized Trial | Cirrhosis is a major and growing global cause of morbidity and premature mortality, driven largely by alcohol-associated liver disease and metabolic dysfunction–associated steatotic liver disease alongside chronic viral hepatitis. | 2 | Sasidharan Swarup (2026) | A randomized controlled trial of L -taurine for fatigue in decompensated cirrhosis |
| Taurine Cognition Randomized Trial | Fatigue in chronic liver disease is a multidimensional syndrome involving reduced physical and mental energy, impaired motivation, reduced endurance, and slowed cognition that is often poorly relieved by rest. | 2 | Sasidharan Swarup (2026) | A randomized controlled trial of L -taurine for fatigue in decompensated cirrhosis |
| Taurine Cognition Randomized Trial | , , Despite its impact, there is no universally effective, guideline-endorsed pharmacologic therapy for fatigue in cirrhosis. | 2 | Sasidharan Swarup (2026) | A randomized controlled trial of L -taurine for fatigue in decompensated cirrhosis |
| Taurine Cognition Randomized Trial | As the cirrhosis population ages and lives longer with decompensation, the clinical focus can no longer remain limited to “hard” outcomes (bleeding, ascites, and encephalopathy) alone; patient-reported outcomes and day-to-day functioning matter because they determine disability, health care use, and whether patients can participate meaningfully in care pathways. | 2 | Sasidharan Swarup (2026) | A randomized controlled trial of L -taurine for fatigue in decompensated cirrhosis |
| Taurine Cognition Randomized Trial | As life expectancy increases, age-associated declines in muscle strength, metabolic flexibility, immune responsiveness, and cognitive resilience have become major contributors to morbidity and diminished quality of life. | 3 | Chen Zhigang (2026) | Taurine and glutamine supplementation in aging: systemic mechanisms, exercise interactions, and modulation of muscular and neurobiological pathways |
| Taurine Cognition Randomized Trial | Despite these benefits, the biological response to exercise is often dampened in aging due to reduced mitochondrial efficiency, lower anabolic sensitivity, impaired antioxidant capacity, and chronic inflammatory signaling. | 3 | Chen Zhigang (2026) | Taurine and glutamine supplementation in aging: systemic mechanisms, exercise interactions, and modulation of muscular and neurobiological pathways |
| Taurine Cognition Randomized Trial | As a result, older adults commonly experience delayed recovery, attenuated gains in muscle strength or aerobic capacity, and limited adaptations compared with younger individuals. | 3 | Chen Zhigang (2026) | Taurine and glutamine supplementation in aging: systemic mechanisms, exercise interactions, and modulation of muscular and neurobiological pathways |
| Taurine Cognition Randomized Trial | Kirkwood, 2005 Lutz and Quinn, 2012 Falahi et al., 2025 Liang et al., 2022 Hébert, 1997 The steady growth of the global older population has intensified scientific attention toward biological processes that erode functional capacity and compromise independence with aging. | 3 | Chen Zhigang (2026) | Taurine and glutamine supplementation in aging: systemic mechanisms, exercise interactions, and modulation of muscular and neurobiological pathways |
Source documents