supplement evidence

Spermidine Supplementation Healthy Aging Randomized Trial Evidence Table

Structured evidence table for Spermidine Supplementation Healthy Aging Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Spermidine Supplementation Healthy Aging Randomized TrialThe positive effect of AM3, spermidine, and hesperidin, which have antioxidant and anti-inflammatory properties, on immunity is known, but their effect on the rate of aging, known as biological age (BA), is unclear.2Félix J (2024)Human Supplementation with AM3, Spermidine, and Hesperidin Enhances Immune Function, Decreases Biological Age, and Improves Oxidative-Inflammatory State: A Randomized Controlled Trial.
Spermidine Supplementation Healthy Aging Randomized TrialThis work aims to test if the intake of a blend of AM3 (150 mg), spermidine (0.6 mg), and hesperidin (50 mg) for 2 months could decrease BA and improve immunity, redox, and inflammatory states.2Félix J (2024)Human Supplementation with AM3, Spermidine, and Hesperidin Enhances Immune Function, Decreases Biological Age, and Improves Oxidative-Inflammatory State: A Randomized Controlled Trial.
Spermidine Supplementation Healthy Aging Randomized TrialAging is closely associated with the increased morbidity and mortality of ischemic cardiovascular disease, at least partially through impaired angiogenic capacity.4Ueno D (2023)Spermidine improves angiogenic capacity of senescent endothelial cells, and enhances ischemia-induced neovascularization in aged mice.
Spermidine Supplementation Healthy Aging Randomized TrialIntracellular polyamine contents were reduced in replicative senescent ECs, which were subsequently recovered by spermidine supplementation.4Ueno D (2023)Spermidine improves angiogenic capacity of senescent endothelial cells, and enhances ischemia-induced neovascularization in aged mice.
Spermidine Supplementation Healthy Aging Randomized TrialOur findings reveal that spermidine supplementation improved the declined angiogenic capacity of senescent ECs, including migration and tube-formation, without affecting the senescence phenotypes.4Ueno D (2023)Spermidine improves angiogenic capacity of senescent endothelial cells, and enhances ischemia-induced neovascularization in aged mice.
Spermidine Supplementation Healthy Aging Randomized TrialEndothelial cells (ECs) play a crucial role in angiogenesis, and their angiogenic capacity declines during aging.4Ueno D (2023)Spermidine improves angiogenic capacity of senescent endothelial cells, and enhances ischemia-induced neovascularization in aged mice.
topicSpermidine Supplementation Healthy Aging Randomized Trial
claimThe positive effect of AM3, spermidine, and hesperidin, which have antioxidant and anti-inflammatory properties, on immunity is known, but their effect on the rate of aging, known as biological age (BA), is unclear.
evidence level2
citationFélix J (2024)
sourceHuman Supplementation with AM3, Spermidine, and Hesperidin Enhances Immune Function, Decreases Biological Age, and Improves Oxidative-Inflammatory State: A Randomized Controlled Trial.
topicSpermidine Supplementation Healthy Aging Randomized Trial
claimThis work aims to test if the intake of a blend of AM3 (150 mg), spermidine (0.6 mg), and hesperidin (50 mg) for 2 months could decrease BA and improve immunity, redox, and inflammatory states.
evidence level2
citationFélix J (2024)
sourceHuman Supplementation with AM3, Spermidine, and Hesperidin Enhances Immune Function, Decreases Biological Age, and Improves Oxidative-Inflammatory State: A Randomized Controlled Trial.
topicSpermidine Supplementation Healthy Aging Randomized Trial
claimAging is closely associated with the increased morbidity and mortality of ischemic cardiovascular disease, at least partially through impaired angiogenic capacity.
evidence level4
citationUeno D (2023)
sourceSpermidine improves angiogenic capacity of senescent endothelial cells, and enhances ischemia-induced neovascularization in aged mice.
topicSpermidine Supplementation Healthy Aging Randomized Trial
claimIntracellular polyamine contents were reduced in replicative senescent ECs, which were subsequently recovered by spermidine supplementation.
evidence level4
citationUeno D (2023)
sourceSpermidine improves angiogenic capacity of senescent endothelial cells, and enhances ischemia-induced neovascularization in aged mice.
topicSpermidine Supplementation Healthy Aging Randomized Trial
claimOur findings reveal that spermidine supplementation improved the declined angiogenic capacity of senescent ECs, including migration and tube-formation, without affecting the senescence phenotypes.
evidence level4
citationUeno D (2023)
sourceSpermidine improves angiogenic capacity of senescent endothelial cells, and enhances ischemia-induced neovascularization in aged mice.
topicSpermidine Supplementation Healthy Aging Randomized Trial
claimEndothelial cells (ECs) play a crucial role in angiogenesis, and their angiogenic capacity declines during aging.
evidence level4
citationUeno D (2023)
sourceSpermidine improves angiogenic capacity of senescent endothelial cells, and enhances ischemia-induced neovascularization in aged mice.

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Source documents

  1. Human Supplementation with AM3, Spermidine, and Hesperidin Enhances Immune Function, Decreases Biological Age, and Improves Oxidative-Inflammatory State: A Randomized Controlled Trial.
  2. Spermidine improves angiogenic capacity of senescent endothelial cells, and enhances ischemia-induced neovascularization in aged mice.