Structured evidence table for Spermidine Skin Aging Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Spermidine Skin Aging Randomized Trial | Interventions that alter metabolite availability or metabolism, such as caloric restriction (CR) or reduced insulin/IGF‐1 signaling (IIS), extend lifespan across species (Gao et al. ). | 3 | Jiang Yizhou (2026) | Lifespan‐Extending Endogenous Metabolites |
| Spermidine Skin Aging Randomized Trial | This review highlights the role of endogenous metabolites in regulating longevity pathways and evaluates evidence across species to aid understanding metabolic regulation of aging and guiding future investigations. | 3 | Jiang Yizhou (2026) | Lifespan‐Extending Endogenous Metabolites |
| Spermidine Skin Aging Randomized Trial | In UVB‐irradiated hairless mice, oral taurine preserved epidermal moisture and significantly reduced wrinkle formation, suggesting an anti‐photoaging action via its osmolyte and moisturizing roles (Yoshimura et al. ). | 3 | Jiang Yizhou (2026) | Lifespan‐Extending Endogenous Metabolites |
| Spermidine Skin Aging Randomized Trial | 2023 2018 2021 2025 2013 Aging is a multifactorial process driven by the interplay of genetic, environmental, and metabolic perturbations, with dysregulated nutrient sensing and metabolic dysfunction recognized as core hallmarks (Lopez‐Otin et al. ). | 3 | Jiang Yizhou (2026) | Lifespan‐Extending Endogenous Metabolites |
| Spermidine Skin Aging Randomized Trial | Background Ageing is associated with reduced resilience to physiological stressors such as infection and surgery. | 4 | Wilson D (2026) | REPROGRAM: REsilience PROmotion with GeRoprotectors: AssessMent of biological effect: Rationale and protocol for a trial of biological effect. |
| Spermidine Skin Aging Randomized Trial | This reduced resilience is believed to be underpinned by the hallmarks of ageing, the key biological mechanisms driving the aged phenotype. | 4 | Wilson D (2026) | REPROGRAM: REsilience PROmotion with GeRoprotectors: AssessMent of biological effect: Rationale and protocol for a trial of biological effect. |
| Spermidine Skin Aging Randomized Trial | Methods and analysis This trial will test the hypothesis that geroprotectors targeted towards biological mechanisms associated with poor resilience can reverse these pathways within a three-week period. | 4 | Wilson D (2026) | REPROGRAM: REsilience PROmotion with GeRoprotectors: AssessMent of biological effect: Rationale and protocol for a trial of biological effect. |
Source documents