Structured evidence table for Soy Isoflavones Bone Turnover Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Soy Isoflavones Bone Turnover Meta-Analysis | Results The combined EUE and Isf treatment significantly improved biomechanical performance of the femur and restored bone mineral content in ovariectomized rats. | 4 | Zhao R (2026) | Eucommia ulmoides extract and soy isoflavones attenuate postmenopausal osteoporosis by modulating bone-specific transcription factors and inflammatory signaling pathways. |
| Soy Isoflavones Bone Turnover Meta-Analysis | Levels of bone formation markers were elevated, whereas indices of bone resorption were reduced. | 4 | Zhao R (2026) | Eucommia ulmoides extract and soy isoflavones attenuate postmenopausal osteoporosis by modulating bone-specific transcription factors and inflammatory signaling pathways. |
| Soy Isoflavones Bone Turnover Meta-Analysis | In vitro , the combination enhanced osteoblast mineralization and proliferation, suppressed osteoclast formation, and increased osteoclast apoptosis. | 4 | Zhao R (2026) | Eucommia ulmoides extract and soy isoflavones attenuate postmenopausal osteoporosis by modulating bone-specific transcription factors and inflammatory signaling pathways. |
| Soy Isoflavones Bone Turnover Meta-Analysis | Background Postmenopausal osteoporosis (PMO) is driven by estrogen deficiency, enhanced osteoclastic activity, impaired osteoblast function, and persistent inflammatory signaling. | 4 | Zhao R (2026) | Eucommia ulmoides extract and soy isoflavones attenuate postmenopausal osteoporosis by modulating bone-specific transcription factors and inflammatory signaling pathways. |
| Soy Isoflavones Bone Turnover Meta-Analysis | This narrative review synthesizes mechanistic, translational, and clinical evidence to clarify the potential skeletal relevance of S-equol. | 4 | Sekikawa A (2025) | S-Equol as a Gut-Derived Phytoestrogen Targeting Estrogen Receptor β: A Promising Bioactive Nutrient for Bone Health in Aging Women and Men: A Narrative Review. |
| Soy Isoflavones Bone Turnover Meta-Analysis | These findings align with preclinical evidence demonstrating that S-equol preserves trabecular microarchitecture, enhances bone strength, and reduces bone turnover. | 4 | Sekikawa A (2025) | S-Equol as a Gut-Derived Phytoestrogen Targeting Estrogen Receptor β: A Promising Bioactive Nutrient for Bone Health in Aging Women and Men: A Narrative Review. |
| Soy Isoflavones Bone Turnover Meta-Analysis | Background/Objectives : Osteoporosis is highly prevalent and contributes substantially to morbidity and mortality, yet long-term concerns about pharmacologic therapies leave a major treatment gap. | 4 | Sekikawa A (2025) | S-Equol as a Gut-Derived Phytoestrogen Targeting Estrogen Receptor β: A Promising Bioactive Nutrient for Bone Health in Aging Women and Men: A Narrative Review. |
| Soy Isoflavones Bone Turnover Meta-Analysis | Soy isoflavones have been investigated as safer alternatives, but results across trials are inconsistent. | 4 | Sekikawa A (2025) | S-Equol as a Gut-Derived Phytoestrogen Targeting Estrogen Receptor β: A Promising Bioactive Nutrient for Bone Health in Aging Women and Men: A Narrative Review. |
Source documents