Structured evidence table for Soy Isoflavones Bone Density Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Soy Isoflavones Bone Density Randomized Trial | R50 group exhibited marked improved histoarchitecture, narrow Haversian canals containing red blood cell-filled vessels, and well-organized bone matrix. | 4 | Hegab DM (2026) | Soy-isoflavone to remedy induced or post-gamma-irradiation periodontitis in rat model. |
| Soy Isoflavones Bone Density Randomized Trial | Conclusion Isoflavones, particularly at a concentration of 50 mg/kg body weight, effectively preserved bone microarchitecture, enhanced vascularization, and promoted periodontal tissue regeneration. | 4 | Hegab DM (2026) | Soy-isoflavone to remedy induced or post-gamma-irradiation periodontitis in rat model. |
| Soy Isoflavones Bone Density Randomized Trial | These findings suggest that isoflavone may serve as a promising adjunctive therapeutic agent for mitigating radiation-associated and inflammatory alveolar bone loss. | 4 | Hegab DM (2026) | Soy-isoflavone to remedy induced or post-gamma-irradiation periodontitis in rat model. |
| Soy Isoflavones Bone Density Randomized Trial | Background Radiotherapy remains a cornerstone in tumour management; however, it can lead to deleterious effects on alveolar bone, including hypovascularity, endarteritis, and osteoradionecrosis. | 4 | Hegab DM (2026) | Soy-isoflavone to remedy induced or post-gamma-irradiation periodontitis in rat model. |
| Soy Isoflavones Bone Density Randomized Trial | Recent evidence highlights the role of dietary metabolites—derived from food components digested by gut microbiota—in regulating bone turnover. | 4 | Caviness Perry C. (2025) | Soy Isoflavones Prevent Bone Quality Loss Induced by High‐Fat Diet in Rats Through Epigenetic Modifications |
| Soy Isoflavones Bone Density Randomized Trial | This can result in increased bone marrow adiposity and decreased bone quality []. | 4 | Caviness Perry C. (2025) | Soy Isoflavones Prevent Bone Quality Loss Induced by High‐Fat Diet in Rats Through Epigenetic Modifications |
| Soy Isoflavones Bone Density Randomized Trial | Our group has found that in rats, SPI dietary supplementation of HFD can ameliorate HFD‐induced negative effects on bone []. | 4 | Caviness Perry C. (2025) | Soy Isoflavones Prevent Bone Quality Loss Induced by High‐Fat Diet in Rats Through Epigenetic Modifications |
| Soy Isoflavones Bone Density Randomized Trial | Akt ALP GAPDH HFD IGF1 IRS1 Isof JNK NEFA OGTT PND 1 2 3 4 1 Nutrition, sex hormones, local paracrine molecules, and physical activity are all known to significantly influence bone modeling and maturation during early life [,]. | 4 | Caviness Perry C. (2025) | Soy Isoflavones Prevent Bone Quality Loss Induced by High‐Fat Diet in Rats Through Epigenetic Modifications |
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