topicSodium Hyaluronate Skin Hydration Randomized Trial
claimSkin hydration/elasticity improved sustainably for 3 months, with only 1.67% adverse events and no serious ones.
evidence level2
citationYang Rongya (2026)
sourceEfficacy and Safety of a Novel Sodium Hyaluronate Composite Solution via Mesotherapy for Facial Rejuvenation: A Multicenter Randomized Controlled Study
topicSodium Hyaluronate Skin Hydration Randomized Trial
claimThis large-scale randomized controlled trial complements the existing evidence base for the novel sodium hyaluronate composite, strongly supporting its safty and clinical efficacy in facial rejuvenation through mesotherapy.
evidence level2
citationYang Rongya (2026)
sourceEfficacy and Safety of a Novel Sodium Hyaluronate Composite Solution via Mesotherapy for Facial Rejuvenation: A Multicenter Randomized Controlled Study
topicSodium Hyaluronate Skin Hydration Randomized Trial
claimThe GAIS score distribution demonstrated that within the treatment group, 5.57% of subjects were rated as “very much improved,” 41.11% as “much improved,” and 50.87% as “improved.” In contrast, only 6 subjects (3.95%) in the control group showed improvement of any degree, whereas the remainder were rated as “no change” or “worse” (Table).
evidence level2
citationYang Rongya (2026)
sourceEfficacy and Safety of a Novel Sodium Hyaluronate Composite Solution via Mesotherapy for Facial Rejuvenation: A Multicenter Randomized Controlled Study
topicSodium Hyaluronate Skin Hydration Randomized Trial
claimIs this novel sodium hyaluronate composite containing 4 amino acids safe and effective for facial rejuvenation when administered via mesotherapy?
evidence level2
citationYang Rongya (2026)
sourceEfficacy and Safety of a Novel Sodium Hyaluronate Composite Solution via Mesotherapy for Facial Rejuvenation: A Multicenter Randomized Controlled Study
topicSodium Hyaluronate Skin Hydration Randomized Trial
claimObjective This study aimed to determine whether liposomal delivery enhances the effects of a collagen tripeptide-containing formulation on dermal structural and biomechanical parameters, as well as appearance-related skin properties, compared with a nonliposomal formulation and placebo.
evidence level2
citationLin YK (2026)
sourceLiposomal Delivery Enhances the Effects of a Collagen Tripeptide-Containing Formulation on Dermal Structure and Optical Skin Parameters: A Randomized, Double-Blind, Placebo-Controlled Trial.
topicSodium Hyaluronate Skin Hydration Randomized Trial
claimMethods In a randomized, double-blind, placebo-controlled trial, 75 healthy adults aged 25-65 years were assigned to receive placebo, a nonliposomal formulation containing collagen tripeptides, or a liposomal formulation containing collagen tripeptides (50 mL/day) for 8 weeks.
evidence level2
citationLin YK (2026)
sourceLiposomal Delivery Enhances the Effects of a Collagen Tripeptide-Containing Formulation on Dermal Structure and Optical Skin Parameters: A Randomized, Double-Blind, Placebo-Controlled Trial.