Structured evidence table for Silymarin Metabolic Health Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Silymarin Metabolic Health Meta-Analysis | Conclusion Silymarin combined with lifestyle modifications is a safe and effective treatment option for reducing and normalizing liver enzyme levels in patients with NAFLD and associated metabolic syndrome. | 4 | Sukeepaisarnjaroen W (2026) | Effectiveness of silymarin with lifestyle intervention in NAFLD and metabolic syndrome: a prospective single-arm study. |
| Silymarin Metabolic Health Meta-Analysis | Background Non-alcoholic fatty liver disease (NAFLD) has now become a major global health concern. | 4 | Sukeepaisarnjaroen W (2026) | Effectiveness of silymarin with lifestyle intervention in NAFLD and metabolic syndrome: a prospective single-arm study. |
| Silymarin Metabolic Health Meta-Analysis | Lifestyle modifications are the first line of treatment; however, their effectiveness is often limited. | 4 | Sukeepaisarnjaroen W (2026) | Effectiveness of silymarin with lifestyle intervention in NAFLD and metabolic syndrome: a prospective single-arm study. |
| Silymarin Metabolic Health Meta-Analysis | Metabolic dysfunction-associated steatotic liver disease (MASLD) is an increasing global health concern with limited effective therapies. | 4 | Tawfik MF (2025) | Targeting metabolic dysfunction-associated steatotic liver disease with phytosomal silymarin and piperine: A natural alternative to fenofibrate in a rat model. |
| Silymarin Metabolic Health Meta-Analysis | The phytocomplex formulation significantly reduced serum ALT, AST, ALP, and GGT, improved lipid profiles, and restored hepatic architecture, with MASLD-AS and PPAR-α expression demonstrating a marked reduction in hepatic injury and oxidative stress. | 4 | Tawfik MF (2025) | Targeting metabolic dysfunction-associated steatotic liver disease with phytosomal silymarin and piperine: A natural alternative to fenofibrate in a rat model. |
| Silymarin Metabolic Health Meta-Analysis | Silymarin exhibits hepatoprotective properties, but its utility is limited by poor bioavailability. | 4 | Tawfik MF (2025) | Targeting metabolic dysfunction-associated steatotic liver disease with phytosomal silymarin and piperine: A natural alternative to fenofibrate in a rat model. |
Source documents