topicSilicon Hair Skin Nails Randomized Trial
claimBackground Biotin, a vital cofactor for carboxylase enzymes, plays a key role in metabolic processes, while silica is believed to support collagen synthesis, contributing to improved skin and hair health.
evidence level2
citationPatel MN (2025)
sourceThe Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
topicSilicon Hair Skin Nails Randomized Trial
claimResults In the post-90-day evaluation, hair fall reduced to 20.61 ± 14.39 (p < 0.001) in biotin and 15.71 ± 10.8 (p < 0.001) in biotin with silica.
evidence level2
citationPatel MN (2025)
sourceThe Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
topicSilicon Hair Skin Nails Randomized Trial
claimHair growth rate increased by 0.55 mm/day (p < 0.0001) in biotin and 0.57 mm/day (p < 0.0001) in biotin with silica.
evidence level2
citationPatel MN (2025)
sourceThe Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
topicSilicon Hair Skin Nails Randomized Trial
claimThis study investigates the dermatological benefits of standardized plant-based supplements formulated with biotin derived from Sesbania grandiflora and a biotin-silica blend extracted from Bambusa arundinacea.
evidence level2
citationPatel MN (2025)
sourceThe Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
topicSilicon Hair Skin Nails Randomized Trial
claimThese effects are hypothesized to arise from enhanced fibroblast activity, increased synthesis of extracellular matrix proteins such as elastin, and reduced expression of matrix metalloproteinases (MMPs) that degrade native collagen.
evidence level4
citationIvaskiene Tatjana (2025)
sourceCollagen supplementation and regenerative health: advances in biomarker detection and smart material integration
topicSilicon Hair Skin Nails Randomized Trial
claimHowever, whileand small-scale clinical studies offer promising results, robust evidence from large randomized controlled trials (RCTs) remains limited ().
evidence level4
citationIvaskiene Tatjana (2025)
sourceCollagen supplementation and regenerative health: advances in biomarker detection and smart material integration
topicSilicon Hair Skin Nails Randomized Trial
claimThis review aims to fill that gap by providing a comprehensive, interdisciplinary synthesis of current clinical evidence, detection technologies, and biomaterial innovations related to collagen.
evidence level4
citationIvaskiene Tatjana (2025)
sourceCollagen supplementation and regenerative health: advances in biomarker detection and smart material integration
topicSilicon Hair Skin Nails Randomized Trial
claim1 2 Collagen is the most abundant structural protein in the human body, comprising approximately 30% of total protein content ().
evidence level4
citationIvaskiene Tatjana (2025)
sourceCollagen supplementation and regenerative health: advances in biomarker detection and smart material integration