topicSilicon Bone Health Randomized Trial
claimOVCFs are associated with significant reductions in health-related quality of life, progressive spinal deformity, and increased mortality risk [,].
evidence level4
citationGazzeri Roberto (2026)
sourceOral Food Supplement with Bio-Activated Silicium and Vitamins D3 and K2 in the Conservative Management of Osteoporotic Vertebral Compression Fractures
topicSilicon Bone Health Randomized Trial
claimMoreover, OVCFs substantially increase the risk of subsequent vertebral fractures by up to fivefold, initiating a cascade of skeletal fragility that further worsens long-term prognosis [,].
evidence level4
citationGazzeri Roberto (2026)
sourceOral Food Supplement with Bio-Activated Silicium and Vitamins D3 and K2 in the Conservative Management of Osteoporotic Vertebral Compression Fractures
topicSilicon Bone Health Randomized Trial
claim7 8 9 10 11 12 13 14 15 Most OVCFs are initially managed conservatively, and current international guidelines recommend non-operative treatment for stable fractures without neurological compromise [,,].
evidence level4
citationGazzeri Roberto (2026)
sourceOral Food Supplement with Bio-Activated Silicium and Vitamins D3 and K2 in the Conservative Management of Osteoporotic Vertebral Compression Fractures
topicSilicon Bone Health Randomized Trial
claim1 2 3 4 5 6 Osteoporotic vertebral compression fractures (OVCFs) are the most common manifestation of osteoporotic skeletal disease and represent a major global public health burden [].
evidence level4
citationGazzeri Roberto (2026)
sourceOral Food Supplement with Bio-Activated Silicium and Vitamins D3 and K2 in the Conservative Management of Osteoporotic Vertebral Compression Fractures