topicSesamin Lipid Markers Randomized Trial
claimMoreover, emerging evidence demonstrates that ferroptosis occurs in endothelial cells, vascular smooth muscle cells, and macrophages within atherosclerotic lesions, suggesting a more direct contribution to plaque vulnerability and vascular dysfunction than other cell death pathways (;;).
evidence level4
citationChen Xiaoying (2026)
sourceSesamin attenuates atherosclerosis by alleviating vascular endothelial ferroptosis-related injury via m 6 A-dependent regulation of SREBF1 expression
topicSesamin Lipid Markers Randomized Trial
claimAccumulating evidence indicates that mA modification and its regulatory enzymes, including METTL3 and FTO, play essential roles in vascular cell function, lipid metabolism, and inflammatory signaling during AS development ().
evidence level4
citationChen Xiaoying (2026)
sourceSesamin attenuates atherosclerosis by alleviating vascular endothelial ferroptosis-related injury via m 6 A-dependent regulation of SREBF1 expression
topicSesamin Lipid Markers Randomized Trial
claimIn this context, recent evidence indicates that SREBF1, traditionally known for its role in lipid metabolism, may exert context-dependent functions under oxidative stress, including regulation of ferroptosis-related antioxidant defenses (;).
evidence level4
citationChen Xiaoying (2026)
sourceSesamin attenuates atherosclerosis by alleviating vascular endothelial ferroptosis-related injury via m 6 A-dependent regulation of SREBF1 expression
topicSesamin Lipid Markers Randomized Trial
claimFan and Watanabe, 2022 Libby, 2021 Hansson and Hermansson, 2011 Zhu et al., 2018 Ma et al., 2022 Ouyang et al., 2021 Xu et al., 2024 Atherosclerosis (AS) is a chronic inflammatory vascular disease and the principal pathological basis of cardiovascular and cerebrovascular disorders.
evidence level4
citationChen Xiaoying (2026)
sourceSesamin attenuates atherosclerosis by alleviating vascular endothelial ferroptosis-related injury via m 6 A-dependent regulation of SREBF1 expression