topicSesame Blood Lipids Meta-Analysis
claimHyperglycaemia is a hallmark of diabetes and a major risk factor for diabetic kidney disease (DKD).
evidence level4
citationLuo X (2026)
sourceLong-Term Impact of Cumulative Hyperglycaemia on DNA Methylation and its Role in Diabetic Kidney Disease
topicSesame Blood Lipids Meta-Analysis
claimHere, we assessed CH-associated DNA methylation in 1,245 participants with type 1 diabetes (T1D) from Finland and the United Kingdom-Republic of Ireland cohorts.
evidence level4
citationLuo X (2026)
sourceLong-Term Impact of Cumulative Hyperglycaemia on DNA Methylation and its Role in Diabetic Kidney Disease
topicSesame Blood Lipids Meta-Analysis
claimWe identified 17 CH-associated CpGs, with the strongest association at cg19693031 ( TXNIP ).
evidence level4
citationLuo X (2026)
sourceLong-Term Impact of Cumulative Hyperglycaemia on DNA Methylation and its Role in Diabetic Kidney Disease
topicSesame Blood Lipids Meta-Analysis
claimHowever, the molecular consequences of long-term cumulative hyperglycaemia (CH) remain unclear.
evidence level4
citationLuo X (2026)
sourceLong-Term Impact of Cumulative Hyperglycaemia on DNA Methylation and its Role in Diabetic Kidney Disease