evidence table

Selenium Thyroid Health Randomized Trial Evidence Table

Name: Selenium Thyroid Health Randomized Trial Evidence Table
Creator: Migaku
License: https://creativecommons.org/licenses/by/4.0/

Structured evidence table for Selenium Thyroid Health Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topic	claim	evidence level	citation	source
Selenium Thyroid Health Randomized Trial	reported that 6 months of Sel improved GO-specific QoL, reduced ocular involvement, and slowed progression in patients with mild GO, supporting its incorporation into European guidance for mild, active GO, particularly in Sel-deficient areas [].	1	Kostadinov Nikolay (2026)	Efficacy of Selenium Supplementation in Graves’ Orbitopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis
Selenium Thyroid Health Randomized Trial	Subsequent studies expanded the evidence base but introduced uncertainty: a Mexican randomized study suggested improved clinical activity and reduced progression in mild GO, whereas trials in Sel-sufficient settings and in inactive moderate-to-severe GO have reported more heterogeneous effects [,,].	1	Kostadinov Nikolay (2026)	Efficacy of Selenium Supplementation in Graves’ Orbitopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis
Selenium Thyroid Health Randomized Trial	Current recommendations are largely influenced by limited trial evidence, and prior syntheses have not fully clarified whether benefits differ by baseline Sel status, GO activity/severity, treatment duration, or outcome domain.	1	Kostadinov Nikolay (2026)	Efficacy of Selenium Supplementation in Graves’ Orbitopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis
Selenium Thyroid Health Randomized Trial	1 2 Graves’ orbitopathy (GO) is an immune-mediated inflammatory disorder of the orbit and periorbital tissues and represents the most common extrathyroidal manifestation of Graves’ disease.	1	Kostadinov Nikolay (2026)	Efficacy of Selenium Supplementation in Graves’ Orbitopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis
Selenium Thyroid Health Randomized Trial	It is associated with elevated anti-thyroid peroxidase antibodies (TPOAb) and often anti-thyroglobulin antibodies (TgAb) ().	4	Personius Lydia (2026)	Beyond levothyroxine: a narrative review of adjunctive management strategies for Hashimoto’s thyroiditis
Selenium Thyroid Health Randomized Trial	The incidence of HT has increased over recent decades and is higher with advancing age, in women, and in iodine-sufficient populations (,).	4	Personius Lydia (2026)	Beyond levothyroxine: a narrative review of adjunctive management strategies for Hashimoto’s thyroiditis
Selenium Thyroid Health Randomized Trial	Wet cupping was associated with a statistically significant reduction in anti-thyroid autoantibody levels and a decrease in TSH despite stable thyroid hormone dosing ().	4	Personius Lydia (2026)	Beyond levothyroxine: a narrative review of adjunctive management strategies for Hashimoto’s thyroiditis
Selenium Thyroid Health Randomized Trial	1 2 3 4 Hashimoto’s thyroiditis (HT) is an autoimmune disorder that has been well documented as the leading cause of hypothyroidism and the most common form of thyroiditis ().	4	Personius Lydia (2026)	Beyond levothyroxine: a narrative review of adjunctive management strategies for Hashimoto’s thyroiditis