evidence table

Selenium Thyroid Function Randomized Trial Evidence Table

Structured evidence table for Selenium Thyroid Function Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Selenium Thyroid Function Randomized Trialreported that 6 months of Sel improved GO-specific QoL, reduced ocular involvement, and slowed progression in patients with mild GO, supporting its incorporation into European guidance for mild, active GO, particularly in Sel-deficient areas [].1Kostadinov Nikolay (2026)Efficacy of Selenium Supplementation in Graves’ Orbitopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis
Selenium Thyroid Function Randomized TrialSubsequent studies expanded the evidence base but introduced uncertainty: a Mexican randomized study suggested improved clinical activity and reduced progression in mild GO, whereas trials in Sel-sufficient settings and in inactive moderate-to-severe GO have reported more heterogeneous effects [,,].1Kostadinov Nikolay (2026)Efficacy of Selenium Supplementation in Graves’ Orbitopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis
Selenium Thyroid Function Randomized TrialCurrent recommendations are largely influenced by limited trial evidence, and prior syntheses have not fully clarified whether benefits differ by baseline Sel status, GO activity/severity, treatment duration, or outcome domain.1Kostadinov Nikolay (2026)Efficacy of Selenium Supplementation in Graves’ Orbitopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis
Selenium Thyroid Function Randomized Trial1 2 Graves’ orbitopathy (GO) is an immune-mediated inflammatory disorder of the orbit and periorbital tissues and represents the most common extrathyroidal manifestation of Graves’ disease.1Kostadinov Nikolay (2026)Efficacy of Selenium Supplementation in Graves’ Orbitopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis
Selenium Thyroid Function Randomized TrialCombination therapy significantly reduced TSH levels compared with Sel monotherapy (SMD -1.26; 95% CI -1.51 to -1.00; p 2 = 0%), and TSA suggested that this finding may be robust, although the evidence is limited by the small number of studies.1Stanchev P (2026)Myo-Inositol Plus Selenium vs. Selenium Alone in Hashimoto's Thyroiditis with Subclinical Hypothyroidism: A Systematic Review and Updated Meta-Analysis with Trial Sequential Analysis.
Selenium Thyroid Function Randomized TrialTgAb levels were also significantly reduced (SMD -0.51; 95% CI -0.78 to -0.24; p 2 = 0%); however, TSA indicated a potential risk of type I error.1Stanchev P (2026)Myo-Inositol Plus Selenium vs. Selenium Alone in Hashimoto's Thyroiditis with Subclinical Hypothyroidism: A Systematic Review and Updated Meta-Analysis with Trial Sequential Analysis.
Selenium Thyroid Function Randomized TrialConclusions : MI combined with Sel was associated with a significant reduction in TSH levels compared with Sel alone in patients with HT and subclinical hypothyroidism, suggesting a potential therapeutic benefit.1Stanchev P (2026)Myo-Inositol Plus Selenium vs. Selenium Alone in Hashimoto's Thyroiditis with Subclinical Hypothyroidism: A Systematic Review and Updated Meta-Analysis with Trial Sequential Analysis.
Selenium Thyroid Function Randomized TrialIntroduction : Hashimoto's thyroiditis (HT) is the leading cause of hypothyroidism in iodine-sufficient regions and often presents with subclinical hypothyroidism.1Stanchev P (2026)Myo-Inositol Plus Selenium vs. Selenium Alone in Hashimoto's Thyroiditis with Subclinical Hypothyroidism: A Systematic Review and Updated Meta-Analysis with Trial Sequential Analysis.
topicSelenium Thyroid Function Randomized Trial
claimreported that 6 months of Sel improved GO-specific QoL, reduced ocular involvement, and slowed progression in patients with mild GO, supporting its incorporation into European guidance for mild, active GO, particularly in Sel-deficient areas [].
evidence level1
citationKostadinov Nikolay (2026)
sourceEfficacy of Selenium Supplementation in Graves’ Orbitopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis
topicSelenium Thyroid Function Randomized Trial
claimSubsequent studies expanded the evidence base but introduced uncertainty: a Mexican randomized study suggested improved clinical activity and reduced progression in mild GO, whereas trials in Sel-sufficient settings and in inactive moderate-to-severe GO have reported more heterogeneous effects [,,].
evidence level1
citationKostadinov Nikolay (2026)
sourceEfficacy of Selenium Supplementation in Graves’ Orbitopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis
topicSelenium Thyroid Function Randomized Trial
claimCurrent recommendations are largely influenced by limited trial evidence, and prior syntheses have not fully clarified whether benefits differ by baseline Sel status, GO activity/severity, treatment duration, or outcome domain.
evidence level1
citationKostadinov Nikolay (2026)
sourceEfficacy of Selenium Supplementation in Graves’ Orbitopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis
topicSelenium Thyroid Function Randomized Trial
claim1 2 Graves’ orbitopathy (GO) is an immune-mediated inflammatory disorder of the orbit and periorbital tissues and represents the most common extrathyroidal manifestation of Graves’ disease.
evidence level1
citationKostadinov Nikolay (2026)
sourceEfficacy of Selenium Supplementation in Graves’ Orbitopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis
topicSelenium Thyroid Function Randomized Trial
claimCombination therapy significantly reduced TSH levels compared with Sel monotherapy (SMD -1.26; 95% CI -1.51 to -1.00; p 2 = 0%), and TSA suggested that this finding may be robust, although the evidence is limited by the small number of studies.
evidence level1
citationStanchev P (2026)
sourceMyo-Inositol Plus Selenium vs. Selenium Alone in Hashimoto's Thyroiditis with Subclinical Hypothyroidism: A Systematic Review and Updated Meta-Analysis with Trial Sequential Analysis.
topicSelenium Thyroid Function Randomized Trial
claimTgAb levels were also significantly reduced (SMD -0.51; 95% CI -0.78 to -0.24; p 2 = 0%); however, TSA indicated a potential risk of type I error.
evidence level1
citationStanchev P (2026)
sourceMyo-Inositol Plus Selenium vs. Selenium Alone in Hashimoto's Thyroiditis with Subclinical Hypothyroidism: A Systematic Review and Updated Meta-Analysis with Trial Sequential Analysis.
topicSelenium Thyroid Function Randomized Trial
claimConclusions : MI combined with Sel was associated with a significant reduction in TSH levels compared with Sel alone in patients with HT and subclinical hypothyroidism, suggesting a potential therapeutic benefit.
evidence level1
citationStanchev P (2026)
sourceMyo-Inositol Plus Selenium vs. Selenium Alone in Hashimoto's Thyroiditis with Subclinical Hypothyroidism: A Systematic Review and Updated Meta-Analysis with Trial Sequential Analysis.
topicSelenium Thyroid Function Randomized Trial
claimIntroduction : Hashimoto's thyroiditis (HT) is the leading cause of hypothyroidism in iodine-sufficient regions and often presents with subclinical hypothyroidism.
evidence level1
citationStanchev P (2026)
sourceMyo-Inositol Plus Selenium vs. Selenium Alone in Hashimoto's Thyroiditis with Subclinical Hypothyroidism: A Systematic Review and Updated Meta-Analysis with Trial Sequential Analysis.

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Source documents

  1. Efficacy of Selenium Supplementation in Graves’ Orbitopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis
  2. Myo-Inositol Plus Selenium vs. Selenium Alone in Hashimoto's Thyroiditis with Subclinical Hypothyroidism: A Systematic Review and Updated Meta-Analysis with Trial Sequential Analysis.