evidence table

Selenium Immune Support Randomized Trial Evidence Table

Name: Selenium Immune Support Randomized Trial Evidence Table
Creator: Migaku
License: https://creativecommons.org/licenses/by/4.0/

Structured evidence table for Selenium Immune Support Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topic	claim	evidence level	citation	source
Selenium Immune Support Randomized Trial	reported that 6 months of Sel improved GO-specific QoL, reduced ocular involvement, and slowed progression in patients with mild GO, supporting its incorporation into European guidance for mild, active GO, particularly in Sel-deficient areas [].	1	Kostadinov Nikolay (2026)	Efficacy of Selenium Supplementation in Graves’ Orbitopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis
Selenium Immune Support Randomized Trial	Subsequent studies expanded the evidence base but introduced uncertainty: a Mexican randomized study suggested improved clinical activity and reduced progression in mild GO, whereas trials in Sel-sufficient settings and in inactive moderate-to-severe GO have reported more heterogeneous effects [,,].	1	Kostadinov Nikolay (2026)	Efficacy of Selenium Supplementation in Graves’ Orbitopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis
Selenium Immune Support Randomized Trial	Current recommendations are largely influenced by limited trial evidence, and prior syntheses have not fully clarified whether benefits differ by baseline Sel status, GO activity/severity, treatment duration, or outcome domain.	1	Kostadinov Nikolay (2026)	Efficacy of Selenium Supplementation in Graves’ Orbitopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis
Selenium Immune Support Randomized Trial	1 2 Graves’ orbitopathy (GO) is an immune-mediated inflammatory disorder of the orbit and periorbital tissues and represents the most common extrathyroidal manifestation of Graves’ disease.	1	Kostadinov Nikolay (2026)	Efficacy of Selenium Supplementation in Graves’ Orbitopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis
Selenium Immune Support Randomized Trial	This review evaluated evidence linking micronutrient status or supplementation with surgical outcomes.	1	Banerjee D (2026)	Role of Micronutrients in Perioperative Care: A Systematic Review.
Selenium Immune Support Randomized Trial	Intravenous iron consistently increased hemoglobin and iron stores but showed variable transfusion effects.	1	Banerjee D (2026)	Role of Micronutrients in Perioperative Care: A Systematic Review.
Selenium Immune Support Randomized Trial	Vitamin C supplementation reduced perioperative pain and modestly improved wound healing.	1	Banerjee D (2026)	Role of Micronutrients in Perioperative Care: A Systematic Review.
Selenium Immune Support Randomized Trial	Background Micronutrient adequacy is essential for wound healing, immune competence, antioxidant defense, and erythropoiesis, all critical to perioperative recovery.	1	Banerjee D (2026)	Role of Micronutrients in Perioperative Care: A Systematic Review.