evidence table

Selenium Immune Function Randomized Trial Evidence Table

Name: Selenium Immune Function Randomized Trial Evidence Table
Creator: Migaku
License: https://creativecommons.org/licenses/by/4.0/

Structured evidence table for Selenium Immune Function Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topic	claim	evidence level	citation	source
Selenium Immune Function Randomized Trial	reported that 6 months of Sel improved GO-specific QoL, reduced ocular involvement, and slowed progression in patients with mild GO, supporting its incorporation into European guidance for mild, active GO, particularly in Sel-deficient areas [].	1	Kostadinov Nikolay (2026)	Efficacy of Selenium Supplementation in Graves’ Orbitopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis
Selenium Immune Function Randomized Trial	Subsequent studies expanded the evidence base but introduced uncertainty: a Mexican randomized study suggested improved clinical activity and reduced progression in mild GO, whereas trials in Sel-sufficient settings and in inactive moderate-to-severe GO have reported more heterogeneous effects [,,].	1	Kostadinov Nikolay (2026)	Efficacy of Selenium Supplementation in Graves’ Orbitopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis
Selenium Immune Function Randomized Trial	Current recommendations are largely influenced by limited trial evidence, and prior syntheses have not fully clarified whether benefits differ by baseline Sel status, GO activity/severity, treatment duration, or outcome domain.	1	Kostadinov Nikolay (2026)	Efficacy of Selenium Supplementation in Graves’ Orbitopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis
Selenium Immune Function Randomized Trial	1 2 Graves’ orbitopathy (GO) is an immune-mediated inflammatory disorder of the orbit and periorbital tissues and represents the most common extrathyroidal manifestation of Graves’ disease.	1	Kostadinov Nikolay (2026)	Efficacy of Selenium Supplementation in Graves’ Orbitopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis
Selenium Immune Function Randomized Trial	Across studies, PBM was associated with reductions in thyroid autoantibodies, improvements in thyroid hormone indices, and decreases in LT4 dose requirements.	1	Berisha-Muharremi V (2026)	Photobiomodulation Therapy in Chronic Autoimmune Thyroiditis: A Systematic Review of Molecular Mechanisms and Clinical Applications.
Selenium Immune Function Randomized Trial	However, current evidence is limited by the small number of human studies, heterogeneous PBM protocols, and the frequent use of concomitant interventions such as selenium or vitamin D.	1	Berisha-Muharremi V (2026)	Photobiomodulation Therapy in Chronic Autoimmune Thyroiditis: A Systematic Review of Molecular Mechanisms and Clinical Applications.
Selenium Immune Function Randomized Trial	Chronic autoimmune thyroiditis (CAT), a common autoimmune thyroid disorder, is the leading cause of hypothyroidism in iodine-sufficient regions and is characterized by thyroid autoimmunity, chronic inflammation, and progressive structural thyroid changes.	1	Berisha-Muharremi V (2026)	Photobiomodulation Therapy in Chronic Autoimmune Thyroiditis: A Systematic Review of Molecular Mechanisms and Clinical Applications.
Selenium Immune Function Randomized Trial	Although levothyroxine (LT4) restores biochemical euthyroidism, it does not directly address the underlying autoimmune process, highlighting the need for adjunctive therapeutic strategies.	1	Berisha-Muharremi V (2026)	Photobiomodulation Therapy in Chronic Autoimmune Thyroiditis: A Systematic Review of Molecular Mechanisms and Clinical Applications.