evidence table
Selenium Cognition Randomized Trial Evidence Table
Structured evidence table for Selenium Cognition Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Selenium Cognition Randomized Trial | For instance, a three-year RCT evaluating the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet showed its potential to slow cognitive decline and reduce brain atrophy in at-risk older adults, as assessed by a validated cognitive battery (). | 3 | Zhang Hailong (2026) | The role of nutrition and multimodal lifestyle interventions in Alzheimer’s prevention and management: a mini-review |
| Selenium Cognition Randomized Trial | Similarly, the two-year Finnish Geriatric Intervention Study (FINGER), a multidomain program encompassing diet, exercise, and cognitive training, was shown to improve global cognition in at-risk elderly, with enhanced benefits observed in carriers of the apolipoprotein E ε4 (APOE4) allele (). | 3 | Zhang Hailong (2026) | The role of nutrition and multimodal lifestyle interventions in Alzheimer’s prevention and management: a mini-review |
| Selenium Cognition Randomized Trial | Subsequent analyses have further revealed that genetic risk profiles, including APOE4 status, can influence responses to interventions targeting factors such as amyloid deposition, thereby underscoring the need for personalized strategies (,). | 3 | Zhang Hailong (2026) | The role of nutrition and multimodal lifestyle interventions in Alzheimer’s prevention and management: a mini-review |
| Selenium Cognition Randomized Trial | 1 2 3–5 6–8 9 10 Alzheimer’s disease (AD) is a progressive neurodegenerative disorder for which no cure currently exists, thereby shifting the research emphasis toward preventive and disease-slowing strategies (,). | 3 | Zhang Hailong (2026) | The role of nutrition and multimodal lifestyle interventions in Alzheimer’s prevention and management: a mini-review |
| Selenium Cognition Randomized Trial | This review summarizes current evidence on nutritional compounds that target aging-related pathways, focusing on interventions that influence mitochondrial health, cognitive performance, immune function, metabolic regulation, and maintenance of muscle mass in older adults. | 4 | Kurtz JA (2026) | Targeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits. |
| Selenium Cognition Randomized Trial | Recent findings Evidence indicates that several targeted nutrients, including protein, probiotics, antioxidants, and emerging mitochondrial-support compounds, may contribute to healthy aging. | 4 | Kurtz JA (2026) | Targeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits. |
| Selenium Cognition Randomized Trial | A personalized, evidence-informed supplementation strategy integrated with exercise and balanced nutrition may help optimize physiological function in aging adults. | 4 | Kurtz JA (2026) | Targeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits. |
| Selenium Cognition Randomized Trial | Purpose of review Aging is marked by progressive physiological decline driven by chronic inflammation, mitochondrial dysfunction, and impaired metabolic and musculoskeletal resilience. | 4 | Kurtz JA (2026) | Targeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits. |
Source documents