topicSaffron Visual Performance Randomized Trial
claimIn recent years, a growing body of scientific evidence supporting several of these traditional uses has shown the potential of saffron and its main ingredients—crocins, crocetin, safranal, and picrocrocin—as pharmacologically relevant compounds.
evidence level3
citationCampos Catarina (2026)
sourceFrom Stigma to Therapy: Pharmacological Insights into Saffron Bioactives for Major Non-Communicable Diseases
topicSaffron Visual Performance Randomized Trial
claimBy integrating evidence from in vitro studies, animal models, and clinical trials, this review critically assesses saffron’s potential as a multi-target pharmacological agent and identifies key limitations and future directions for its development within pharmaceutical and integrative medicine frameworks.
evidence level3
citationCampos Catarina (2026)
sourceFrom Stigma to Therapy: Pharmacological Insights into Saffron Bioactives for Major Non-Communicable Diseases
topicSaffron Visual Performance Randomized Trial
claimConsidering the scope of disease areas covered, this review is intended to be a broad narrative overview rather than an exhaustive systematic evaluation of each disease, with a focus on critically evaluating study quality, level of evidence, gaps between preclinical findings and clinical applicability, and limitations across sections.
evidence level3
citationCampos Catarina (2026)
sourceFrom Stigma to Therapy: Pharmacological Insights into Saffron Bioactives for Major Non-Communicable Diseases
topicSaffron Visual Performance Randomized Trial
claimCrocus sativus 1 2 3 4 5 6 Natural products remain one of the main sources of pharmacologically bioactive compounds (BACs) and have played a fundamental role in the development of new drugs.
evidence level3
citationCampos Catarina (2026)
sourceFrom Stigma to Therapy: Pharmacological Insights into Saffron Bioactives for Major Non-Communicable Diseases
topicSaffron Visual Performance Randomized Trial
claimGrowing evidence highlights the therapeutic promise of non-pharmacological interventions, notably saffron ( Crocus sativus L.) and structured exercise, both of which exert pleiotropic effects through antioxidant, anti-inflammatory, and neuroprotective pathways.
evidence level4
citationLi L (2025)
sourceIntegrative effects of saffron and physical activity on endurance performance, quality of life, cognitive, emotional, and metabolic outcomes in age-related and neurodegenerative diseases.
topicSaffron Visual Performance Randomized Trial
claimAge-related diseases, including cardiovascular disorders, type 2 diabetes, neurodegenerative conditions such as Alzheimer's and Parkinson's disease, and age-related eye diseases, represent leading causes of disability and mortality worldwide.
evidence level4
citationLi L (2025)
sourceIntegrative effects of saffron and physical activity on endurance performance, quality of life, cognitive, emotional, and metabolic outcomes in age-related and neurodegenerative diseases.