Structured evidence table for Saffron Visual Fatigue Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Saffron Visual Fatigue Randomized Trial | 7 9 The standard of care for many IRDs has largely focused on managing associated complications and the use of optical aids to improve quality of life. | 4 | Barthelemy Normila (2026) | Nutritional supplements: current evidence for retinitis pigmentosa and Stargardt disease |
| Saffron Visual Fatigue Randomized Trial | This review synthesizes both historical and contemporary evidence regarding dietary and nutritional interventions for IRDs.  14 Retinitis pigmentosa is one of the most common IRDs and is characterized by progressive photoreceptor cell death. | 4 | Barthelemy Normila (2026) | Nutritional supplements: current evidence for retinitis pigmentosa and Stargardt disease |
| Saffron Visual Fatigue Randomized Trial | By applying next-generation sequencing (NGS) technology to DNA samples stored from patients of the previous vitamin A trials, they were able to identify the specific RP gene variants for most participants and the lack of protective effect across genetic subtypes such as,and-associated retinitis pigmentosa []. | 4 | Barthelemy Normila (2026) | Nutritional supplements: current evidence for retinitis pigmentosa and Stargardt disease |
| Saffron Visual Fatigue Randomized Trial | 1 4 5 6 Inherited retinal diseases (IRDs) comprise a complex group of heterogenous disorders that lead to progressive retinal cell death and functional vision loss. | 4 | Barthelemy Normila (2026) | Nutritional supplements: current evidence for retinitis pigmentosa and Stargardt disease |
| Saffron Visual Fatigue Randomized Trial | Growing evidence highlights the therapeutic promise of non-pharmacological interventions, notably saffron ( Crocus sativus L.) and structured exercise, both of which exert pleiotropic effects through antioxidant, anti-inflammatory, and neuroprotective pathways. | 4 | Li L (2025) | Integrative effects of saffron and physical activity on endurance performance, quality of life, cognitive, emotional, and metabolic outcomes in age-related and neurodegenerative diseases. |
| Saffron Visual Fatigue Randomized Trial | Age-related diseases, including cardiovascular disorders, type 2 diabetes, neurodegenerative conditions such as Alzheimer's and Parkinson's disease, and age-related eye diseases, represent leading causes of disability and mortality worldwide. | 4 | Li L (2025) | Integrative effects of saffron and physical activity on endurance performance, quality of life, cognitive, emotional, and metabolic outcomes in age-related and neurodegenerative diseases. |
Source documents