topicSaffron Mood Symptoms Meta-Analysis
claimSaffron was also associated with greater improvements in self-esteem (adjusted mean difference: 1.43; 95% CI: 0.22, 2.64; d = 0.51; p = 0.022) and sleep-related impairment (adjusted mean difference: 2.99; 95% CI: 0.12, 5.86; d = 0.45; p = 0.041).
evidence level2
citationLopresti AL (2026)
sourceThe effects of a saffron extract (Affron®) on mood, sleep, self-esteem, and exploratory measures of physical appearance in women aged 50 to 70 years experiencing low mood and poor sleep: a randomised, double-blind, placebo-controlled trial.
topicSaffron Mood Symptoms Meta-Analysis
claimConclusion Supplementation with a saffron extract (Affron®) for 12 weeks was associated with improvements in depressive symptoms.
evidence level2
citationLopresti AL (2026)
sourceThe effects of a saffron extract (Affron®) on mood, sleep, self-esteem, and exploratory measures of physical appearance in women aged 50 to 70 years experiencing low mood and poor sleep: a randomised, double-blind, placebo-controlled trial.
topicSaffron Mood Symptoms Meta-Analysis
claimBackground Depression is commonly accompanied by sleep disturbances and low self-esteem.
evidence level2
citationLopresti AL (2026)
sourceThe effects of a saffron extract (Affron®) on mood, sleep, self-esteem, and exploratory measures of physical appearance in women aged 50 to 70 years experiencing low mood and poor sleep: a randomised, double-blind, placebo-controlled trial.
topicSaffron Mood Symptoms Meta-Analysis
claimSaffron ( Crocus sativus L.) has demonstrated antidepressant and sleep-enhancing effects in previous clinical trials; however, its efficacy in women experiencing both low mood and poor sleep has not been specifically examined.
evidence level2
citationLopresti AL (2026)
sourceThe effects of a saffron extract (Affron®) on mood, sleep, self-esteem, and exploratory measures of physical appearance in women aged 50 to 70 years experiencing low mood and poor sleep: a randomised, double-blind, placebo-controlled trial.
topicSaffron Mood Symptoms Meta-Analysis
claim1 1 2 3 4 Low mood is a commonly reported subjective experience in the general population and is often characterized by transient feelings of sadness, reduced motivation, or diminished emotional well-being [].
evidence level2
citationMuacevic Alexander (2026)
sourceStandardized Saffron Extract Formulation for Low Mood and Subclinical Depressive Symptoms: A Randomized, Double-Blind, Placebo-Controlled Trial
topicSaffron Mood Symptoms Meta-Analysis
claimConventional antidepressants are primarily indicated for moderate to severe depression and are associated with delayed onset of action, potential adverse effects, and adherence challenges [-].
evidence level2
citationMuacevic Alexander (2026)
sourceStandardized Saffron Extract Formulation for Low Mood and Subclinical Depressive Symptoms: A Randomized, Double-Blind, Placebo-Controlled Trial
topicSaffron Mood Symptoms Meta-Analysis
claimA growing body of evidence from randomized controlled trials and meta-analyses indicates that saffron supplementation significantly reduces depressive symptoms, with efficacy comparable to conventional antidepressants in individuals with mild to moderate depression [-].
evidence level2
citationMuacevic Alexander (2026)
sourceStandardized Saffron Extract Formulation for Low Mood and Subclinical Depressive Symptoms: A Randomized, Double-Blind, Placebo-Controlled Trial
topicSaffron Mood Symptoms Meta-Analysis
claimA considerable proportion of individuals experiencing low mood also exhibit measurable depressive symptoms that fall within the subclinical to mild range, but do not meet diagnostic criteria for major depressive disorder (MDD) [].
evidence level2
citationMuacevic Alexander (2026)
sourceStandardized Saffron Extract Formulation for Low Mood and Subclinical Depressive Symptoms: A Randomized, Double-Blind, Placebo-Controlled Trial