topicSaffron Cognitive Fatigue Randomized Trial
claimDifficulties in accessing healthcare, their high costs, personal preferences, and the perceived safety of medicinal herbs have contributed to the increased usage of herbalism [,,].
evidence level1
citationHasheminasab Fatemeh Sadat (2026)
sourceAdverse Events of Saffron ( Crocus sativus L.): Systematic Review of Current Evidence
topicSaffron Cognitive Fatigue Randomized Trial
claimGiven their popularity, it is crucial to have up‐to‐date risk and benefit assessments on these herbal products [].
evidence level1
citationHasheminasab Fatemeh Sadat (2026)
sourceAdverse Events of Saffron ( Crocus sativus L.): Systematic Review of Current Evidence
topicSaffron Cognitive Fatigue Randomized Trial
claimTherefore, compiling a systematic review of human studies with the aim of summarizing the available evidence on the side effects ofnot only fills the gap in the literature but also seems essential for physicians, researchers, and health policymakers to use this widely used medicinal plant safely and rationally.
evidence level1
citationHasheminasab Fatemeh Sadat (2026)
sourceAdverse Events of Saffron ( Crocus sativus L.): Systematic Review of Current Evidence
topicSaffron Cognitive Fatigue Randomized Trial
claimsativus 1 1 2 2 3 Saffron (L.) is a sophisticated spice with culinary and therapeutic importance [].
evidence level1
citationHasheminasab Fatemeh Sadat (2026)
sourceAdverse Events of Saffron ( Crocus sativus L.): Systematic Review of Current Evidence
topicSaffron Cognitive Fatigue Randomized Trial
claimThis narrative review critically evaluates clinical evidence on commonly used herbal preparations, with particular emphasis on herb-drug interactions, adverse effects, and issues related to product adulteration.
evidence level3
citationCăuș MN (2026)
sourceEfficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks.
topicSaffron Cognitive Fatigue Randomized Trial
claimHowever, clinically relevant risks were identified, including cytochrome P450-mediated drug interactions, excessive sedation, serotonin syndrome, and toxic effects associated with adulterated products, such as hepatotoxicity, cardiovascular events, and neurological disturbances.
evidence level3
citationCăuș MN (2026)
sourceEfficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks.
topicSaffron Cognitive Fatigue Randomized Trial
claimIncreased awareness of herb-drug interactions and stricter quality control are essential to optimize therapeutic outcomes and minimize harm.
evidence level3
citationCăuș MN (2026)
sourceEfficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks.
topicSaffron Cognitive Fatigue Randomized Trial
claimBackground/Objectives: Plant-based supplements are widely used for the management of anxiety, depression, and insomnia.
evidence level3
citationCăuș MN (2026)
sourceEfficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks.