topicSaffron Anxiety Randomized Trial
claimHowever, due to some potentially significant adverse events associated with its medicinal use at higher doses or prolonged administration, clinical monitoring should be considered.
evidence level1
citationHasheminasab FS (2026)
sourceAdverse Events of Saffron (<i>Crocus sativus</i> L.): Systematic Review of Current Evidence.
topicSaffron Anxiety Randomized Trial
claimBackground Crocus sativus L., commonly known as saffron, is a widely used spice with a rich history of culinary and medicinal applications.
evidence level1
citationHasheminasab FS (2026)
sourceAdverse Events of Saffron (<i>Crocus sativus</i> L.): Systematic Review of Current Evidence.
topicSaffron Anxiety Randomized Trial
claimThis systematic review aims to compile human data from studies on monopreparations of C.
evidence level1
citationHasheminasab FS (2026)
sourceAdverse Events of Saffron (<i>Crocus sativus</i> L.): Systematic Review of Current Evidence.
topicSaffron Anxiety Randomized Trial
claimThis narrative review critically evaluates clinical evidence on commonly used herbal preparations, with particular emphasis on herb-drug interactions, adverse effects, and issues related to product adulteration.
evidence level3
citationCăuș MN (2026)
sourceEfficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks.
topicSaffron Anxiety Randomized Trial
claimHowever, clinically relevant risks were identified, including cytochrome P450-mediated drug interactions, excessive sedation, serotonin syndrome, and toxic effects associated with adulterated products, such as hepatotoxicity, cardiovascular events, and neurological disturbances.
evidence level3
citationCăuș MN (2026)
sourceEfficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks.
topicSaffron Anxiety Randomized Trial
claimIncreased awareness of herb-drug interactions and stricter quality control are essential to optimize therapeutic outcomes and minimize harm.
evidence level3
citationCăuș MN (2026)
sourceEfficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks.
topicSaffron Anxiety Randomized Trial
claimBackground/Objectives: Plant-based supplements are widely used for the management of anxiety, depression, and insomnia.
evidence level3
citationCăuș MN (2026)
sourceEfficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks.