topicSafflower Skin Hydration Randomized Trial
claimFurthermore, the polyphenol and antioxidant contents of snake fruit pulp have been reported to be higher than those found in mango and mangosteen, and comparable to levels observed in kiwifruit [].
evidence level2
citationIntakhiao Suwipa (2026)
sourceEffects of Snake Fruit–Infused Massage Oil With Traditional Thai Massage on Skin Quality: A Randomized Controlled Trial
topicSafflower Skin Hydration Randomized Trial
claim4 5 6 In the field of nutricosmetics, research has primarily focused on bioactive compounds with the ability to inhibit skin‐aging enzymes, as well as those possessing antimicrobial, antioxidant, and anti‐inflammatory properties, all of which contribute to improved skin health and protective effects against environmental stressors [].
evidence level2
citationIntakhiao Suwipa (2026)
sourceEffects of Snake Fruit–Infused Massage Oil With Traditional Thai Massage on Skin Quality: A Randomized Controlled Trial
topicSafflower Skin Hydration Randomized Trial
claimNotably, a study using ethanolic extract of snake fruit reported that a topical cream containing 3% extract significantly reduced the skin melanin index, supporting its potential application in skin‐lightening formulations [].
evidence level2
citationIntakhiao Suwipa (2026)
sourceEffects of Snake Fruit–Infused Massage Oil With Traditional Thai Massage on Skin Quality: A Randomized Controlled Trial
topicSafflower Skin Hydration Randomized Trial
claimSalacca zalacca 1 2 3 , commonly known as snake fruit, is a tropical fruit cultivated in several Southeast Asian countries, including Thailand.
evidence level2
citationIntakhiao Suwipa (2026)
sourceEffects of Snake Fruit–Infused Massage Oil With Traditional Thai Massage on Skin Quality: A Randomized Controlled Trial
topicSafflower Skin Hydration Randomized Trial
claimConclusion An oral skincare supplement combining wheat oil extract and hyaluronic acid offers a comprehensive method for addressing skin aging, providing measurable clinical improvements in various skin parameters and enhancing subjective perceptions of skin health and appearance.
evidence level2
citationGrier-Welch AM (2025)
sourceEfficacy of an Oral Skincare Supplement on Skin Aging: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial.
topicSafflower Skin Hydration Randomized Trial
claimIntroduction Aging leads to structural and compositional changes in the skin, contributing to more wrinkles, less smoothness, and dryness.
evidence level2
citationGrier-Welch AM (2025)
sourceEfficacy of an Oral Skincare Supplement on Skin Aging: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial.
topicSafflower Skin Hydration Randomized Trial
claimThere is growing interest in oral non-invasive interventions to help ameliorate visual signs of skin aging.
evidence level2
citationGrier-Welch AM (2025)
sourceEfficacy of an Oral Skincare Supplement on Skin Aging: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial.