Structured evidence table for Safflower Oil Cholesterol Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Safflower Oil Cholesterol Randomized Trial | Effects of Canola Oil on Hepatic and Cardiometabolic Markers in Non‐Alcoholic Fatty Liver Disease: A Systematic Review and Meta‐Analysis | 1 | Ege Gündüz K (2026) | Effects of Canola Oil on Hepatic and Cardiometabolic Markers in Non‐Alcoholic Fatty Liver Disease: A Systematic Review and Meta‐Analysis |
| Safflower Oil Cholesterol Randomized Trial | Increased dietary LA has contributed to a pervasive imbalance in dietary-6 relative to-3 polyunsaturated fatty acids (PUFA) that has been proposed to affect the incidence and progression of chronic diseases [,,]. | 2 | Sergeant Susan (2026) | Effect of Dietary Linoleic Acid Intake on Eicosapentaenoic Acid Status and Lipoxygenase-Mediated Oxylipin Biosynthesis in Healthy Adults: A Randomized Controlled Trial |
| Safflower Oil Cholesterol Randomized Trial | 13 14 15 16 17 18 19 20 n n n n n n Early guidance to increase dietary LA stemmed from the diet–heart hypothesis of the 1960s–1970s, which proposed that replacing saturated fats with LA-rich vegetable oils would lower serum cholesterol, thereby reducing the risk of atherosclerosis and coronary heart disease. | 2 | Sergeant Susan (2026) | Effect of Dietary Linoleic Acid Intake on Eicosapentaenoic Acid Status and Lipoxygenase-Mediated Oxylipin Biosynthesis in Healthy Adults: A Randomized Controlled Trial |
| Safflower Oil Cholesterol Randomized Trial | A re-analysis of the Sydney Diet Heart Study showed that replacing saturated fat with high-LA safflower oil markedly increased all-cause and cardiovascular mortality despite lowering cholesterol []. | 2 | Sergeant Susan (2026) | Effect of Dietary Linoleic Acid Intake on Eicosapentaenoic Acid Status and Lipoxygenase-Mediated Oxylipin Biosynthesis in Healthy Adults: A Randomized Controlled Trial |
| Safflower Oil Cholesterol Randomized Trial | 1 2 3 4 5 6 7 8 9 10 11 12 n n n Over the past century, shifts in agricultural practices toward the industrial production of commodity crops, particularly soybeans and corn, have transformed the global food supply and sparked a scientific and public health debate [,,,]. | 2 | Sergeant Susan (2026) | Effect of Dietary Linoleic Acid Intake on Eicosapentaenoic Acid Status and Lipoxygenase-Mediated Oxylipin Biosynthesis in Healthy Adults: A Randomized Controlled Trial |
Source documents