gut health

Saccharomyces Boulardii Antibiotic-Associated Diarrhea Meta-Analysis Evidence Table

Structured evidence table for Saccharomyces Boulardii Antibiotic-Associated Diarrhea Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Saccharomyces Boulardii Antibiotic-Associated Diarrhea Meta-AnalysisIntroduction: Antibiotic-associated diarrhea (AAD) is a common complication of antibiotic therapy, while evidence supporting Saccharomyces boulardii for its prevention among hospitalized adults in resource-constrained settings remains limited.2Kovacevic P (2026)<i>Saccharomyces boulardii</i> for the Prevention of Antibiotic-Associated Diarrhea in Hospitalized Patients Receiving Antibiotics: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Trial.
Saccharomyces Boulardii Antibiotic-Associated Diarrhea Meta-AnalysisAAD occurred in 4/51 participants (7.8%) receiving Bularen ® and 35/49 (71.4%) receiving placebo (risk ratio, 0.11; 95% confidence interval, 0.04-0.29; p p p Clostridioides difficile infections were identified.2Kovacevic P (2026)<i>Saccharomyces boulardii</i> for the Prevention of Antibiotic-Associated Diarrhea in Hospitalized Patients Receiving Antibiotics: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Trial.
Saccharomyces Boulardii Antibiotic-Associated Diarrhea Meta-AnalysisConclusions: Bularen ® substantially reduced AAD incidence in this study population.2Kovacevic P (2026)<i>Saccharomyces boulardii</i> for the Prevention of Antibiotic-Associated Diarrhea in Hospitalized Patients Receiving Antibiotics: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Trial.
Saccharomyces Boulardii Antibiotic-Associated Diarrhea Meta-AnalysisWe evaluated the efficacy of Bularen ® in preventing AAD among hospitalized adults receiving systemic antibiotics.2Kovacevic P (2026)<i>Saccharomyces boulardii</i> for the Prevention of Antibiotic-Associated Diarrhea in Hospitalized Patients Receiving Antibiotics: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Trial.
Saccharomyces Boulardii Antibiotic-Associated Diarrhea Meta-AnalysisAs a result, it does not reach the colon and is not expected to affect the colonic microbiota.2Hodzhev Vladimir (2025)High-dose Probiotic Mix of Lactobacillus spp., Bifidobacterium spp., Bacillus coagulans, and Saccharomyces boulardii to Prevent Antibiotic-associated Diarrhea in Adults: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial (SPAADA)
Saccharomyces Boulardii Antibiotic-Associated Diarrhea Meta-AnalysisThe study aimed to evaluate the probiotic mix for preventing antibiotic-associated diarrhea in adults.2Hodzhev Vladimir (2025)High-dose Probiotic Mix of Lactobacillus spp., Bifidobacterium spp., Bacillus coagulans, and Saccharomyces boulardii to Prevent Antibiotic-associated Diarrhea in Adults: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial (SPAADA)
Saccharomyces Boulardii Antibiotic-Associated Diarrhea Meta-AnalysisTo the Editor 1 2  —We appreciate our colleagues’ interest in our work [] and thank the editors for the opportunity to address concerns and expand discussion of our findings.2Hodzhev Vladimir (2025)High-dose Probiotic Mix of Lactobacillus spp., Bifidobacterium spp., Bacillus coagulans, and Saccharomyces boulardii to Prevent Antibiotic-associated Diarrhea in Adults: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial (SPAADA)
Saccharomyces Boulardii Antibiotic-Associated Diarrhea Meta-AnalysisIn response, we contacted the manufacturer of the product, Neopharm Bulgaria, for detailed information on the excipients included in the capsules [].2Hodzhev Vladimir (2025)High-dose Probiotic Mix of Lactobacillus spp., Bifidobacterium spp., Bacillus coagulans, and Saccharomyces boulardii to Prevent Antibiotic-associated Diarrhea in Adults: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial (SPAADA)
topicSaccharomyces Boulardii Antibiotic-Associated Diarrhea Meta-Analysis
claimIntroduction: Antibiotic-associated diarrhea (AAD) is a common complication of antibiotic therapy, while evidence supporting Saccharomyces boulardii for its prevention among hospitalized adults in resource-constrained settings remains limited.
evidence level2
citationKovacevic P (2026)
source<i>Saccharomyces boulardii</i> for the Prevention of Antibiotic-Associated Diarrhea in Hospitalized Patients Receiving Antibiotics: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Trial.
topicSaccharomyces Boulardii Antibiotic-Associated Diarrhea Meta-Analysis
claimAAD occurred in 4/51 participants (7.8%) receiving Bularen ® and 35/49 (71.4%) receiving placebo (risk ratio, 0.11; 95% confidence interval, 0.04-0.29; p p p Clostridioides difficile infections were identified.
evidence level2
citationKovacevic P (2026)
source<i>Saccharomyces boulardii</i> for the Prevention of Antibiotic-Associated Diarrhea in Hospitalized Patients Receiving Antibiotics: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Trial.
topicSaccharomyces Boulardii Antibiotic-Associated Diarrhea Meta-Analysis
claimConclusions: Bularen ® substantially reduced AAD incidence in this study population.
evidence level2
citationKovacevic P (2026)
source<i>Saccharomyces boulardii</i> for the Prevention of Antibiotic-Associated Diarrhea in Hospitalized Patients Receiving Antibiotics: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Trial.
topicSaccharomyces Boulardii Antibiotic-Associated Diarrhea Meta-Analysis
claimWe evaluated the efficacy of Bularen ® in preventing AAD among hospitalized adults receiving systemic antibiotics.
evidence level2
citationKovacevic P (2026)
source<i>Saccharomyces boulardii</i> for the Prevention of Antibiotic-Associated Diarrhea in Hospitalized Patients Receiving Antibiotics: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Trial.
topicSaccharomyces Boulardii Antibiotic-Associated Diarrhea Meta-Analysis
claimAs a result, it does not reach the colon and is not expected to affect the colonic microbiota.
evidence level2
citationHodzhev Vladimir (2025)
sourceHigh-dose Probiotic Mix of Lactobacillus spp., Bifidobacterium spp., Bacillus coagulans, and Saccharomyces boulardii to Prevent Antibiotic-associated Diarrhea in Adults: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial (SPAADA)
topicSaccharomyces Boulardii Antibiotic-Associated Diarrhea Meta-Analysis
claimThe study aimed to evaluate the probiotic mix for preventing antibiotic-associated diarrhea in adults.
evidence level2
citationHodzhev Vladimir (2025)
sourceHigh-dose Probiotic Mix of Lactobacillus spp., Bifidobacterium spp., Bacillus coagulans, and Saccharomyces boulardii to Prevent Antibiotic-associated Diarrhea in Adults: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial (SPAADA)
topicSaccharomyces Boulardii Antibiotic-Associated Diarrhea Meta-Analysis
claimTo the Editor 1 2  —We appreciate our colleagues’ interest in our work [] and thank the editors for the opportunity to address concerns and expand discussion of our findings.
evidence level2
citationHodzhev Vladimir (2025)
sourceHigh-dose Probiotic Mix of Lactobacillus spp., Bifidobacterium spp., Bacillus coagulans, and Saccharomyces boulardii to Prevent Antibiotic-associated Diarrhea in Adults: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial (SPAADA)
topicSaccharomyces Boulardii Antibiotic-Associated Diarrhea Meta-Analysis
claimIn response, we contacted the manufacturer of the product, Neopharm Bulgaria, for detailed information on the excipients included in the capsules [].
evidence level2
citationHodzhev Vladimir (2025)
sourceHigh-dose Probiotic Mix of Lactobacillus spp., Bifidobacterium spp., Bacillus coagulans, and Saccharomyces boulardii to Prevent Antibiotic-associated Diarrhea in Adults: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial (SPAADA)

Learn next

Related evidence and supplement guides

AnswerDoes Saccharomyces Boulardii Antibiotic-Associated Diarrhea Meta-Analysis work?Legacy library material — check the original sources.AnswerIs Saccharomyces Boulardii Antibiotic-Associated Diarrhea Meta-Analysis safe?Legacy library material — check the original sources.AnswerWhat does the evidence say about Saccharomyces Boulardii Antibiotic-Associated Diarrhea Meta-Analysis?Legacy library material — check the original sources.AnswerDoes Prebiotic Xylooligosaccharides Gut Health Randomized Trial work?Legacy library material — check the original sources.

Source documents

  1. <i>Saccharomyces boulardii</i> for the Prevention of Antibiotic-Associated Diarrhea in Hospitalized Patients Receiving Antibiotics: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Trial.
  2. High-dose Probiotic Mix of Lactobacillus spp., Bifidobacterium spp., Bacillus coagulans, and Saccharomyces boulardii to Prevent Antibiotic-associated Diarrhea in Adults: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial (SPAADA)