Structured evidence table for Ribose Exercise Fatigue Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Ribose Exercise Fatigue Randomized Trial | If pyruvate cannot be completely metabolized by aerobic oxidation, LDHA will mediate the transformation of pyruvate into lactate; in contrast, LDHB mediates the transformation of lactate into pyruvate when pyruvate is significantly reduced () (;). | 3 | Huang Tianhao (2025) | Novel insights into athlete physical recovery concerning lactate metabolism, lactate clearance and fatigue monitoring: A comprehensive review |
| Ribose Exercise Fatigue Randomized Trial | Pyruvate is converted to acetyl-CoA with pyruvate dehydrogenase catalytic reaction, and acetyl-CoA plus oxaloacetate generate citrate to initiate TCA cycle, thereby the oxidation rate of lactate is associated with the TCA cycle initiator oxaloacetate () (). | 3 | Huang Tianhao (2025) | Novel insights into athlete physical recovery concerning lactate metabolism, lactate clearance and fatigue monitoring: A comprehensive review |
| Ribose Exercise Fatigue Randomized Trial | Kim et al., 2010 During exercise, skeletal muscle contraction causes mechanical compression of vascular endothelial cells, and the reduced blood flow aggravates hypoxia process. | 3 | Huang Tianhao (2025) | Novel insights into athlete physical recovery concerning lactate metabolism, lactate clearance and fatigue monitoring: A comprehensive review |
| Ribose Exercise Fatigue Randomized Trial | Von Duvilard et al., 2004 Kaviani et al., 2020 Kruk et al., 2021 Kamińska et al., 2020 Zhu et al., 2020 After long-time and high-intensity training and competition, the body of athletes will show fatigue due to excess carbohydrate consumption and oxidation function decline, followed by metabolic imbalance, cell membrane oxidative damage, serum lactate accumulation (;;). | 3 | Huang Tianhao (2025) | Novel insights into athlete physical recovery concerning lactate metabolism, lactate clearance and fatigue monitoring: A comprehensive review |
| Ribose Exercise Fatigue Randomized Trial | Excessive exercise induces muscle damage, inflammation, oxidative stress, abnormal mitochondrial function, and reduced glycogen content. | 4 | Crisol Barbara M. (2025) | Excessive exercise elicits poly (ADP-ribose) Polymerase-1 activation and global protein PARylation driving muscle dysfunction and performance impairment |
| Ribose Exercise Fatigue Randomized Trial | These skeletal muscle alterations are often associated with low oxidative capacity, muscle weakness, pain, and performance worsening [,,,]. | 4 | Crisol Barbara M. (2025) | Excessive exercise elicits poly (ADP-ribose) Polymerase-1 activation and global protein PARylation driving muscle dysfunction and performance impairment |
| Ribose Exercise Fatigue Randomized Trial | However, unfortunately, there is no specific therapy to prevent or treat skeletal muscle disorders associated with the NFOR and the overtraining syndrome. | 4 | Crisol Barbara M. (2025) | Excessive exercise elicits poly (ADP-ribose) Polymerase-1 activation and global protein PARylation driving muscle dysfunction and performance impairment |
| Ribose Exercise Fatigue Randomized Trial | [1] [2] [3] [4] [1] [2] [3] [4] [5] [6] [7] 5 [8] [9] [10] Excessive physical exercise without sufficient recovery time typically leads to muscle damage, performance stagnation, or decline, which can have serious consequences for both athletes and non-athletes. | 4 | Crisol Barbara M. (2025) | Excessive exercise elicits poly (ADP-ribose) Polymerase-1 activation and global protein PARylation driving muscle dysfunction and performance impairment |
Source documents