topicRhubarb Constipation Randomized Trial
claimThe etiology of not only physical but also mental disorders that dominate current morbidity and mortality worldwide is associated with chronic inflammation.
evidence level3
citationKolodziejczyk-Czepas Joanna (2025)
sourceRhubarb as a Potential Component of an Anti-Inflammatory Diet
topicRhubarb Constipation Randomized Trial
claimAccording to the literature, more than 50% of all deaths in Western civilization are related to inflammation-associated diseases such as cardiovascular diseases, diabetes mellitus, cancer, non-alcoholic fatty liver disease (NAFLD), autoimmune diseases, and chronic kidney disease, as well as neurodegenerative disorders.
evidence level3
citationKolodziejczyk-Czepas Joanna (2025)
sourceRhubarb as a Potential Component of an Anti-Inflammatory Diet
topicRhubarb Constipation Randomized Trial
claimThe anti-inflammatory effects of various dietary components are attributed to their ability to modulate pro-inflammatory gene expression and block the initiation of the pro-inflammatory signaling pathways, as well as suppress inflammation-associated oxidative stress.
evidence level3
citationKolodziejczyk-Czepas Joanna (2025)
sourceRhubarb as a Potential Component of an Anti-Inflammatory Diet
topicRhubarb Constipation Randomized Trial
claim1 2 2 3 Inflammation has evolved as a multistep and multilevel process constituting the first line of the animal body’s defense against harmful stimuli such as injuries, pathogens, and other irritants.
evidence level3
citationKolodziejczyk-Czepas Joanna (2025)
sourceRhubarb as a Potential Component of an Anti-Inflammatory Diet
topicRhubarb Constipation Randomized Trial
claimAnimal studies demonstrated that rhubarb significantly increased ACh in the mice ileum (p = 0.0023) and serum AChE levels (p < 0.0001).
evidence level4
citationWen Z (2026)
sourceRhubarb enhances gastrointestinal motility via calcium-mediated intestinal acetylcholine release: a network pharmacology study.
topicRhubarb Constipation Randomized Trial
claimRapid restoration of intestinal motility is crucial in managing acute pancreatitis (AP), particularly in severe cases.
evidence level4
citationWen Z (2026)
sourceRhubarb enhances gastrointestinal motility via calcium-mediated intestinal acetylcholine release: a network pharmacology study.
topicRhubarb Constipation Randomized Trial
claimThis study aims to investigate the potential of Chinese medicinal rhubarb to enhance bowel motility through modulation of calcium ion signaling in the gastrointestinal tract.
evidence level4
citationWen Z (2026)
sourceRhubarb enhances gastrointestinal motility via calcium-mediated intestinal acetylcholine release: a network pharmacology study.