supplement evidence

Resveratrol Vascular Function Meta-Analysis Evidence Table

Structured evidence table for Resveratrol Vascular Function Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Resveratrol Vascular Function Meta-AnalysisEndothelial function and autoregulation were markedly reduced, which was accompanied by increased ROS and RNS in retinal blood vessels of vehicle-exposed mice following I/R, whereas resveratrol preserved vascular endothelial function and autoregulation and blunted ROS and RNS formation.4Chronopoulos P (2023)Effects of Resveratrol on Vascular Function in Retinal Ischemia-Reperfusion Injury.
Resveratrol Vascular Function Meta-AnalysisMoreover, resveratrol reduced I/R-induced mRNA expression for the prooxidant enzyme, nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2).4Chronopoulos P (2023)Effects of Resveratrol on Vascular Function in Retinal Ischemia-Reperfusion Injury.
Resveratrol Vascular Function Meta-AnalysisOur data provide evidence that resveratrol protects from I/R-induced retinal ganglion cell loss and endothelial dysfunction in the murine retina by reducing nitro-oxidative stress possibly via suppression of NOX2 upregulation.4Chronopoulos P (2023)Effects of Resveratrol on Vascular Function in Retinal Ischemia-Reperfusion Injury.
Resveratrol Vascular Function Meta-AnalysisIschemia-reperfusion (I/R) events are involved in the development of various ocular pathologies, e.g., retinal artery or vein occlusion.4Chronopoulos P (2023)Effects of Resveratrol on Vascular Function in Retinal Ischemia-Reperfusion Injury.
Resveratrol Vascular Function Meta-AnalysisResveratrol increases the production of nitric oxide (NO) in endothelial cells by upregulating the expression of endothelial NO synthase (eNOS), stimulating eNOS enzymatic activity, and preventing eNOS uncoupling.4Li H (2019)Resveratrol and Vascular Function.
Resveratrol Vascular Function Meta-AnalysisAt the same time, resveratrol inhibits the synthesis of endothelin-1 and reduces oxidative stress in both endothelial cells and smooth muscle cells.4Li H (2019)Resveratrol and Vascular Function.
topicResveratrol Vascular Function Meta-Analysis
claimEndothelial function and autoregulation were markedly reduced, which was accompanied by increased ROS and RNS in retinal blood vessels of vehicle-exposed mice following I/R, whereas resveratrol preserved vascular endothelial function and autoregulation and blunted ROS and RNS formation.
evidence level4
citationChronopoulos P (2023)
sourceEffects of Resveratrol on Vascular Function in Retinal Ischemia-Reperfusion Injury.
topicResveratrol Vascular Function Meta-Analysis
claimMoreover, resveratrol reduced I/R-induced mRNA expression for the prooxidant enzyme, nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2).
evidence level4
citationChronopoulos P (2023)
sourceEffects of Resveratrol on Vascular Function in Retinal Ischemia-Reperfusion Injury.
topicResveratrol Vascular Function Meta-Analysis
claimOur data provide evidence that resveratrol protects from I/R-induced retinal ganglion cell loss and endothelial dysfunction in the murine retina by reducing nitro-oxidative stress possibly via suppression of NOX2 upregulation.
evidence level4
citationChronopoulos P (2023)
sourceEffects of Resveratrol on Vascular Function in Retinal Ischemia-Reperfusion Injury.
topicResveratrol Vascular Function Meta-Analysis
claimIschemia-reperfusion (I/R) events are involved in the development of various ocular pathologies, e.g., retinal artery or vein occlusion.
evidence level4
citationChronopoulos P (2023)
sourceEffects of Resveratrol on Vascular Function in Retinal Ischemia-Reperfusion Injury.
topicResveratrol Vascular Function Meta-Analysis
claimResveratrol increases the production of nitric oxide (NO) in endothelial cells by upregulating the expression of endothelial NO synthase (eNOS), stimulating eNOS enzymatic activity, and preventing eNOS uncoupling.
evidence level4
citationLi H (2019)
sourceResveratrol and Vascular Function.
topicResveratrol Vascular Function Meta-Analysis
claimAt the same time, resveratrol inhibits the synthesis of endothelin-1 and reduces oxidative stress in both endothelial cells and smooth muscle cells.
evidence level4
citationLi H (2019)
sourceResveratrol and Vascular Function.

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Source documents

  1. Effects of Resveratrol on Vascular Function in Retinal Ischemia-Reperfusion Injury.
  2. Resveratrol and Vascular Function.