Resveratrol Skin Health Randomized Trial Evidence Table

Structured evidence table for Resveratrol Skin Health Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Resveratrol Skin Health Randomized TrialResults indicated significantly reduced wrinkle scores in the A/A Group compared to the P/P Group at week 8.2Rao A (2025)Trans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial.
Resveratrol Skin Health Randomized TrialAll treatment groups showed increased sebum levels, with the active topical groups (P/A and A/A Groups) having significantly higher U-zone sebum at week 8 compared to placebo topical groups (P/P and A/P Groups).2Rao A (2025)Trans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial.
Resveratrol Skin Health Randomized TrialSerum trans-resveratrol conjugate levels increased significantly in the A/P and A/A Groups at week 4 and 8.2Rao A (2025)Trans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial.
Resveratrol Skin Health Randomized TrialIntroduction This double-blind, randomised, placebo-controlled clinical study evaluated the effects of trans-resveratrol on skin health.2Rao A (2025)Trans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial.
Resveratrol Skin Health Randomized TrialNotably, the concentration of PIC required for certain in vitro activities remains higher than those typically achieved in vivo, and the current evidence base for PIC in human skin is considerably less developed than that for resveratrol.3Zhang Dian (2026)Piceatannol from Passion Fruit Seed Waste: A Circular Bioeconomy-Driven Pathway Toward a Skin-Targeted Bioactive
Resveratrol Skin Health Randomized TrialWe aim to: (1) synthesize the evidence for PIC’s multi-target activity in skin aging and acne; (2) critically evaluate existing in vivo and clinical data to identify key evidence gaps; and (3) propose a phase-gate translational framework that prioritizes standardization, sustainable sourcing, nano-delivery, and clinical validation.3Zhang Dian (2026)Piceatannol from Passion Fruit Seed Waste: A Circular Bioeconomy-Driven Pathway Toward a Skin-Targeted Bioactive
Resveratrol Skin Health Randomized TrialFigure 3 Table 1 29 A robust body of in vitro and ex vivo evidence delineates PIC’s pleiotropic effects across the interconnected pathways driving skin aging and dysfunction, as summarized inand.3Zhang Dian (2026)Piceatannol from Passion Fruit Seed Waste: A Circular Bioeconomy-Driven Pathway Toward a Skin-Targeted Bioactive
Resveratrol Skin Health Randomized TrialPassiflora edulis 1 2 Figure 1 3 The global juice processing industry generates substantial quantities of passion fruit () seed waste, an agro-industrial byproduct that is often underutilized or discarded [,] ().3Zhang Dian (2026)Piceatannol from Passion Fruit Seed Waste: A Circular Bioeconomy-Driven Pathway Toward a Skin-Targeted Bioactive
topicResveratrol Skin Health Randomized Trial
claimResults indicated significantly reduced wrinkle scores in the A/A Group compared to the P/P Group at week 8.
evidence level2
citationRao A (2025)
sourceTrans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial.
topicResveratrol Skin Health Randomized Trial
claimAll treatment groups showed increased sebum levels, with the active topical groups (P/A and A/A Groups) having significantly higher U-zone sebum at week 8 compared to placebo topical groups (P/P and A/P Groups).
evidence level2
citationRao A (2025)
sourceTrans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial.
topicResveratrol Skin Health Randomized Trial
claimSerum trans-resveratrol conjugate levels increased significantly in the A/P and A/A Groups at week 4 and 8.
evidence level2
citationRao A (2025)
sourceTrans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial.
topicResveratrol Skin Health Randomized Trial
claimIntroduction This double-blind, randomised, placebo-controlled clinical study evaluated the effects of trans-resveratrol on skin health.
evidence level2
citationRao A (2025)
sourceTrans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial.
topicResveratrol Skin Health Randomized Trial
claimNotably, the concentration of PIC required for certain in vitro activities remains higher than those typically achieved in vivo, and the current evidence base for PIC in human skin is considerably less developed than that for resveratrol.
evidence level3
citationZhang Dian (2026)
sourcePiceatannol from Passion Fruit Seed Waste: A Circular Bioeconomy-Driven Pathway Toward a Skin-Targeted Bioactive
topicResveratrol Skin Health Randomized Trial
claimWe aim to: (1) synthesize the evidence for PIC’s multi-target activity in skin aging and acne; (2) critically evaluate existing in vivo and clinical data to identify key evidence gaps; and (3) propose a phase-gate translational framework that prioritizes standardization, sustainable sourcing, nano-delivery, and clinical validation.
evidence level3
citationZhang Dian (2026)
sourcePiceatannol from Passion Fruit Seed Waste: A Circular Bioeconomy-Driven Pathway Toward a Skin-Targeted Bioactive
topicResveratrol Skin Health Randomized Trial
claimFigure 3 Table 1 29 A robust body of in vitro and ex vivo evidence delineates PIC’s pleiotropic effects across the interconnected pathways driving skin aging and dysfunction, as summarized inand.
evidence level3
citationZhang Dian (2026)
sourcePiceatannol from Passion Fruit Seed Waste: A Circular Bioeconomy-Driven Pathway Toward a Skin-Targeted Bioactive
topicResveratrol Skin Health Randomized Trial
claimPassiflora edulis 1 2 Figure 1 3 The global juice processing industry generates substantial quantities of passion fruit () seed waste, an agro-industrial byproduct that is often underutilized or discarded [,] ().
evidence level3
citationZhang Dian (2026)
sourcePiceatannol from Passion Fruit Seed Waste: A Circular Bioeconomy-Driven Pathway Toward a Skin-Targeted Bioactive

Source documents

  1. Trans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial.
  2. Piceatannol from Passion Fruit Seed Waste: A Circular Bioeconomy-Driven Pathway Toward a Skin-Targeted Bioactive