evidence table

Resveratrol Skin Aging Randomized Trial Evidence Table

Structured evidence table for Resveratrol Skin Aging Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Resveratrol Skin Aging Randomized TrialObjective This study aimed to determine whether liposomal delivery enhances the effects of a collagen tripeptide-containing formulation on dermal structural and biomechanical parameters, as well as appearance-related skin properties, compared with a nonliposomal formulation and placebo.2Lin YK (2026)Liposomal Delivery Enhances the Effects of a Collagen Tripeptide-Containing Formulation on Dermal Structure and Optical Skin Parameters: A Randomized, Double-Blind, Placebo-Controlled Trial.
Resveratrol Skin Aging Randomized TrialMethods In a randomized, double-blind, placebo-controlled trial, 75 healthy adults aged 25-65 years were assigned to receive placebo, a nonliposomal formulation containing collagen tripeptides, or a liposomal formulation containing collagen tripeptides (50 mL/day) for 8 weeks.2Lin YK (2026)Liposomal Delivery Enhances the Effects of a Collagen Tripeptide-Containing Formulation on Dermal Structure and Optical Skin Parameters: A Randomized, Double-Blind, Placebo-Controlled Trial.
Resveratrol Skin Aging Randomized TrialNotably, the concentration of PIC required for certain in vitro activities remains higher than those typically achieved in vivo, and the current evidence base for PIC in human skin is considerably less developed than that for resveratrol.3Zhang Dian (2026)Piceatannol from Passion Fruit Seed Waste: A Circular Bioeconomy-Driven Pathway Toward a Skin-Targeted Bioactive
Resveratrol Skin Aging Randomized TrialWe aim to: (1) synthesize the evidence for PIC’s multi-target activity in skin aging and acne; (2) critically evaluate existing in vivo and clinical data to identify key evidence gaps; and (3) propose a phase-gate translational framework that prioritizes standardization, sustainable sourcing, nano-delivery, and clinical validation.3Zhang Dian (2026)Piceatannol from Passion Fruit Seed Waste: A Circular Bioeconomy-Driven Pathway Toward a Skin-Targeted Bioactive
Resveratrol Skin Aging Randomized TrialFigure 3 Table 1 29 A robust body of in vitro and ex vivo evidence delineates PIC’s pleiotropic effects across the interconnected pathways driving skin aging and dysfunction, as summarized inand.3Zhang Dian (2026)Piceatannol from Passion Fruit Seed Waste: A Circular Bioeconomy-Driven Pathway Toward a Skin-Targeted Bioactive
Resveratrol Skin Aging Randomized TrialPassiflora edulis 1 2 Figure 1 3 The global juice processing industry generates substantial quantities of passion fruit () seed waste, an agro-industrial byproduct that is often underutilized or discarded [,] ().3Zhang Dian (2026)Piceatannol from Passion Fruit Seed Waste: A Circular Bioeconomy-Driven Pathway Toward a Skin-Targeted Bioactive
topicResveratrol Skin Aging Randomized Trial
claimObjective This study aimed to determine whether liposomal delivery enhances the effects of a collagen tripeptide-containing formulation on dermal structural and biomechanical parameters, as well as appearance-related skin properties, compared with a nonliposomal formulation and placebo.
evidence level2
citationLin YK (2026)
sourceLiposomal Delivery Enhances the Effects of a Collagen Tripeptide-Containing Formulation on Dermal Structure and Optical Skin Parameters: A Randomized, Double-Blind, Placebo-Controlled Trial.
topicResveratrol Skin Aging Randomized Trial
claimMethods In a randomized, double-blind, placebo-controlled trial, 75 healthy adults aged 25-65 years were assigned to receive placebo, a nonliposomal formulation containing collagen tripeptides, or a liposomal formulation containing collagen tripeptides (50 mL/day) for 8 weeks.
evidence level2
citationLin YK (2026)
sourceLiposomal Delivery Enhances the Effects of a Collagen Tripeptide-Containing Formulation on Dermal Structure and Optical Skin Parameters: A Randomized, Double-Blind, Placebo-Controlled Trial.
topicResveratrol Skin Aging Randomized Trial
claimNotably, the concentration of PIC required for certain in vitro activities remains higher than those typically achieved in vivo, and the current evidence base for PIC in human skin is considerably less developed than that for resveratrol.
evidence level3
citationZhang Dian (2026)
sourcePiceatannol from Passion Fruit Seed Waste: A Circular Bioeconomy-Driven Pathway Toward a Skin-Targeted Bioactive
topicResveratrol Skin Aging Randomized Trial
claimWe aim to: (1) synthesize the evidence for PIC’s multi-target activity in skin aging and acne; (2) critically evaluate existing in vivo and clinical data to identify key evidence gaps; and (3) propose a phase-gate translational framework that prioritizes standardization, sustainable sourcing, nano-delivery, and clinical validation.
evidence level3
citationZhang Dian (2026)
sourcePiceatannol from Passion Fruit Seed Waste: A Circular Bioeconomy-Driven Pathway Toward a Skin-Targeted Bioactive
topicResveratrol Skin Aging Randomized Trial
claimFigure 3 Table 1 29 A robust body of in vitro and ex vivo evidence delineates PIC’s pleiotropic effects across the interconnected pathways driving skin aging and dysfunction, as summarized inand.
evidence level3
citationZhang Dian (2026)
sourcePiceatannol from Passion Fruit Seed Waste: A Circular Bioeconomy-Driven Pathway Toward a Skin-Targeted Bioactive
topicResveratrol Skin Aging Randomized Trial
claimPassiflora edulis 1 2 Figure 1 3 The global juice processing industry generates substantial quantities of passion fruit () seed waste, an agro-industrial byproduct that is often underutilized or discarded [,] ().
evidence level3
citationZhang Dian (2026)
sourcePiceatannol from Passion Fruit Seed Waste: A Circular Bioeconomy-Driven Pathway Toward a Skin-Targeted Bioactive

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Source documents

  1. Liposomal Delivery Enhances the Effects of a Collagen Tripeptide-Containing Formulation on Dermal Structure and Optical Skin Parameters: A Randomized, Double-Blind, Placebo-Controlled Trial.
  2. Piceatannol from Passion Fruit Seed Waste: A Circular Bioeconomy-Driven Pathway Toward a Skin-Targeted Bioactive