topicResveratrol Endothelial Function Randomized Trial
claimBackground and aims Menopause is an important cardiovascular risk factor in women likely due to marked estrogen decline.
evidence level2
citationGonçalinho GHF (2026)
sourceThe effects of resveratrol on endothelial progenitor cells and apoptosis biomarkers in postmenopausal women with chronic coronary heart disease: a randomized controlled trial.
topicResveratrol Endothelial Function Randomized Trial
claimConclusion Resveratrol increased serum Bcl-2 and cIAP2, and also reduced caspase 9 and circulating EPCs in postmenopausal women with chronic CHD, likely unrelated to circulating SIRT1 and SIRT3.
evidence level2
citationGonçalinho GHF (2026)
sourceThe effects of resveratrol on endothelial progenitor cells and apoptosis biomarkers in postmenopausal women with chronic coronary heart disease: a randomized controlled trial.
topicResveratrol Endothelial Function Randomized Trial
claimThe effects of resveratrol treatment in this population group should be assessed with caution, as a reduction in EPCs is associated with impaired endothelial function and an increased risk of cardiovascular disease.
evidence level2
citationGonçalinho GHF (2026)
sourceThe effects of resveratrol on endothelial progenitor cells and apoptosis biomarkers in postmenopausal women with chronic coronary heart disease: a randomized controlled trial.
topicResveratrol Endothelial Function Randomized Trial
claimEstrogens affect key processes in atherosclerosis, maintaining endothelial integrity by inhibiting endothelial apoptosis and promoting regeneration through endothelial progenitor cells (EPCs).
evidence level2
citationGonçalinho GHF (2026)
sourceThe effects of resveratrol on endothelial progenitor cells and apoptosis biomarkers in postmenopausal women with chronic coronary heart disease: a randomized controlled trial.
topicResveratrol Endothelial Function Randomized Trial
claimThese abnormalities result from deficient insulin secretion (type 1), resistance to the action of insulin (type 2), or both [].
evidence level3
citationMuharib Dina (2026)
sourceModulatory Effects of Polyphenols on Altered Leukocyte Functions in Thromboinflammation and Diabetes Mellitus
topicResveratrol Endothelial Function Randomized Trial
claimThe global prevalence of DM has increased dramatically in recent decades, particularly through an increase in type 2 DM (T2DM) driven by a global rise in obesity.
evidence level3
citationMuharib Dina (2026)
sourceModulatory Effects of Polyphenols on Altered Leukocyte Functions in Thromboinflammation and Diabetes Mellitus
topicResveratrol Endothelial Function Randomized Trial
claimIn addition to traditional cardiovascular risk factors, DM is recognized as a thromboinflammatory condition characterized by dysregulated haemostasis and chronic low-grade inflammation [,].
evidence level3
citationMuharib Dina (2026)
sourceModulatory Effects of Polyphenols on Altered Leukocyte Functions in Thromboinflammation and Diabetes Mellitus
topicResveratrol Endothelial Function Randomized Trial
claim1 2 3 4 5 Diabetes mellitus (DM) is a group of metabolic disorders characterized by persistent hyperglycaemia defined as a fasting plasma glucose level ≥ 7.0 mmol/L or a random plasma glucose level ≥ 11.1 mmol/L in presence of symptoms or signs of DM or hemoglobin A1c (HbA1c) exceeding 48 mmol/mol [].
evidence level3
citationMuharib Dina (2026)
sourceModulatory Effects of Polyphenols on Altered Leukocyte Functions in Thromboinflammation and Diabetes Mellitus