topicQuercetin Seasonal Allergy Randomized Trial
claimCurrent therapies mainly alleviate symptoms without addressing underlying immune dysfunction, which has increased interest in nutritional bioactive compounds as preventive or modulatory agents.
evidence level3
citationZafrilla P (2025)
sourceDietary Bioactive Compounds and Their Role in Allergy Prevention: A Comprehensive Review.
topicQuercetin Seasonal Allergy Randomized Trial
claimThis review summarizes evidence on omega-3 polyunsaturated fatty acids, vitamin D, curcumin, ginger bioactives, quercetin, and epigallocatechin gallate (EGCG) in allergy prevention and management.
evidence level3
citationZafrilla P (2025)
sourceDietary Bioactive Compounds and Their Role in Allergy Prevention: A Comprehensive Review.
topicQuercetin Seasonal Allergy Randomized Trial
claimGinger constituents ([6]-gingerol, [6]-shogaol) modulate Th1/Th2 balance, mast-cell activity, and oxidative stress, with early clinical evidence in rhinitis and asthma.
evidence level3
citationZafrilla P (2025)
sourceDietary Bioactive Compounds and Their Role in Allergy Prevention: A Comprehensive Review.
topicQuercetin Seasonal Allergy Randomized Trial
claimBackground/Objectives: Allergic diseases are highly prevalent worldwide and represent a significant public health burden.
evidence level3
citationZafrilla P (2025)
sourceDietary Bioactive Compounds and Their Role in Allergy Prevention: A Comprehensive Review.
topicQuercetin Seasonal Allergy Randomized Trial
claimThe primary pathogenic mechanism of Type I hypersensitivity reactions involves histamine-mediated activation of the H1 receptor (H1R) and the subsequent signaling of the phospholipase C β-inositol trisphosphate (PLCβ-IP 3 ) pathway.
evidence level4
citationFrati F (2026)
sourcePreclinical In Vitro Evaluation of an Innovative Nutraceutical Mixture Modulating the Histamine H1 Receptor-Preliminary Data.
topicQuercetin Seasonal Allergy Randomized Trial
claimThe present study evaluates the in vitro efficacy of a novel nutraceutical mixture-Quercetin, Perilla frutescens , Boswellia serrata , Blackcurrant, Parthenium , Helichrysum , Lactobacillus Acidophilus ( L.
evidence level4
citationFrati F (2026)
sourcePreclinical In Vitro Evaluation of an Innovative Nutraceutical Mixture Modulating the Histamine H1 Receptor-Preliminary Data.