topicPterostilbene Menopause Symptoms Randomized Trial
claimReduced estradiol levels have been associated with undesirable symptoms of the menopause transition.
evidence level2
citationHolmes HE (2026)
sourceNicotinamide riboside and pterostilbene reduces frequency and severity of undesirable symptoms of the menopause transition: an open-label, pilot clinical trial.
topicPterostilbene Menopause Symptoms Randomized Trial
claimAs anticipated NRPT intake significantly increased urinary levels of methyl-nicotinamide (Me-NAM) as well as the methylated pyridone carboxamides (Me-PYs) in all groups.
evidence level2
citationHolmes HE (2026)
sourceNicotinamide riboside and pterostilbene reduces frequency and severity of undesirable symptoms of the menopause transition: an open-label, pilot clinical trial.
topicPterostilbene Menopause Symptoms Randomized Trial
claimIntroduction Nicotinamide adenine dinucleotide (NAD+) is a metabolite of vitamin B3 necessary for the production of key hormones like estradiol.
evidence level2
citationHolmes HE (2026)
sourceNicotinamide riboside and pterostilbene reduces frequency and severity of undesirable symptoms of the menopause transition: an open-label, pilot clinical trial.
topicPterostilbene Menopause Symptoms Randomized Trial
claimThis structural diversity presents a vast landscape for exploring stilbenes with enhanced potency, improved bioavailability, and targeted therapeutic actions against specific NDs,.
evidence level3
citationBegh Md. Zamshed Alam (2024)
sourceTargeting Neurological Disorders with Stilbenes: Bridging the Preclinical-Clinical Gap
topicPterostilbene Menopause Symptoms Randomized Trial
claimThey have been found to exert their beneficial effects through various mechanisms, including antioxidant activity, anti-inflammatory effects, enhancement of neurotrophic factors, protein aggregation inhibition, and modulation of autophagy.
evidence level3
citationBegh Md. Zamshed Alam (2024)
sourceTargeting Neurological Disorders with Stilbenes: Bridging the Preclinical-Clinical Gap
topicPterostilbene Menopause Symptoms Randomized Trial
claimDespite the promising preclinical evidence, significant research is needed to translate these benefits into clinical applications fully.
evidence level3
citationBegh Md. Zamshed Alam (2024)
sourceTargeting Neurological Disorders with Stilbenes: Bridging the Preclinical-Clinical Gap
topicPterostilbene Menopause Symptoms Randomized Trial
claim1 2 3 4 5 6 7 8 9 Neurological disorders (NDs) encompass a diverse group of debilitating conditions that affect the nervous system, including the brain, spinal cord, nerves, and muscles.
evidence level3
citationBegh Md. Zamshed Alam (2024)
sourceTargeting Neurological Disorders with Stilbenes: Bridging the Preclinical-Clinical Gap