topicPsyllium Supplementation Gut Health Randomized Trial
claimA study conducted by Daviddemonstrated a positive correlation between long-term fibre intake and the baselinegenus abundance in human.Additionally, they found a significant rise in β diversity after just 2 days of transitioning to a nearly zero-fibre (animal-based) diet.
evidence level3
citationAsim Fatima (2023)
sourceHow do tumours outside the gastrointestinal tract respond to dietary fibre supplementation?
topicPsyllium Supplementation Gut Health Randomized Trial
claimAbsence of GPR109A has been linked to the development of CRC and other inflammatory processes.GPR43 was found to be absent in metastatic cells and colon tumours, implying a role in carcinogenesis.
evidence level3
citationAsim Fatima (2023)
sourceHow do tumours outside the gastrointestinal tract respond to dietary fibre supplementation?
topicPsyllium Supplementation Gut Health Randomized Trial
claimBoth immune and non-immune mediated mechanisms have been described.In some instances, metabolites from bacterial fermentation of dietary fibre mediate tumour-suppressive activity.For example, β-glucan fromyeast has been shown to decrease tumour growth of prostatic adenocarcinomaand reduce metastatic melanoma in the lungs, associated with activation of monocytes,in mice.
evidence level3
citationAsim Fatima (2023)
sourceHow do tumours outside the gastrointestinal tract respond to dietary fibre supplementation?
topicPsyllium Supplementation Gut Health Randomized Trial
claim1 Cancer remains a significant global health challenge, with 9.6 million deaths attributed to it in 2018, making it the second leading cause of mortality worldwide after cardiovascular disease.Despite advancements in anticancer treatments such as surgery, chemotherapy, radiotherapy and immunotherapy, patients with advanced-stage cancer often have a poor prognosis due to inadequate treatment responses.
evidence level3
citationAsim Fatima (2023)
sourceHow do tumours outside the gastrointestinal tract respond to dietary fibre supplementation?
topicPsyllium Supplementation Gut Health Randomized Trial
claimCAZymes differential analysis revealed an increased abundance of carbohydrate metabolism enzymes in response to dietary fiber supplementation, with distinct microbial community compositions observed among different fiber treatments.
evidence level4
citationLu W (2025)
sourceEffects of dietary fiber on the composition, function, and symbiotic interactions of intestinal microbiota in pre-weaned calves.
topicPsyllium Supplementation Gut Health Randomized Trial
claimIntroduction Dietary fiber plays a crucial role in maintaining gastrointestinal health.
evidence level4
citationLu W (2025)
sourceEffects of dietary fiber on the composition, function, and symbiotic interactions of intestinal microbiota in pre-weaned calves.
topicPsyllium Supplementation Gut Health Randomized Trial
claimHowever, its protective effects on the intestinal health of calves remain to be fully elucidated.
evidence level4
citationLu W (2025)
sourceEffects of dietary fiber on the composition, function, and symbiotic interactions of intestinal microbiota in pre-weaned calves.