Structured evidence table for Propolis Skin Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Propolis Skin Randomized Trial | The risk of dental caries increases with the continuous consumption of carbohydrates and sugar, resulting in increased acidity and disruption of the oral microbial balance. | 3 | Irmaleny Irmaleny (2026) | The Potential of Aloe vera as a Caries Prevention Agent in the Future: A Scoping Review |
| Propolis Skin Randomized Trial | However, CPP-ACP has a drawback—it poses a high risk for lactose-intolerant individuals and is expensive [,]. | 3 | Irmaleny Irmaleny (2026) | The Potential of Aloe vera as a Caries Prevention Agent in the Future: A Scoping Review |
| Propolis Skin Randomized Trial | Based on the current state of affairs, this study was conducted to discuss and provide scientific evidence supporting the use ofas an alternative agent for inducing cavity prevention in order to provide a suitable environment for promoting remineralization and inhibiting demineralization. | 3 | Irmaleny Irmaleny (2026) | The Potential of Aloe vera as a Caries Prevention Agent in the Future: A Scoping Review |
| Propolis Skin Randomized Trial | Excessive acid production leads to a dysbiotic shift in the bacteria, compromising the biofilm, leading to tooth demineralization and dental caries []. | 3 | Irmaleny Irmaleny (2026) | The Potential of Aloe vera as a Caries Prevention Agent in the Future: A Scoping Review |
| Propolis Skin Randomized Trial | Critically, senescent cells adopt a pro‐inflammatory Senescence‐Associated Secretory Phenotype (SASP), secreting cytokines (IL‐6, IL‐8), chemokines, and matrix metalloproteinases (MMPs) that drive chronic low‐grade inflammation (“inflammaging”) and extracellular matrix degradation []. | 4 | Radić Božo (2026) | Senomorphic Activity of a Novel Standardized Propolis Extract in Human Dermal Fibroblasts: Molecular Insights Into Clinically Proven Anti‐Wrinkle Efficacy |
| Propolis Skin Randomized Trial | 1 This study provides the first evidence that a chemically defined, standardized propolis extract acts as a senomorphic agent in human dermal fibroblasts. | 4 | Radić Božo (2026) | Senomorphic Activity of a Novel Standardized Propolis Extract in Human Dermal Fibroblasts: Molecular Insights Into Clinically Proven Anti‐Wrinkle Efficacy |
| Propolis Skin Randomized Trial | These molecular findings provide mechanistic insights consistent with the extract's clinically proven anti‐wrinkle efficacy [], supporting its positioning as a scientifically validated active ingredient for evidence‐based dermo‐cosmetic formulations targeting skin inflammaging. | 4 | Radić Božo (2026) | Senomorphic Activity of a Novel Standardized Propolis Extract in Human Dermal Fibroblasts: Molecular Insights Into Clinically Proven Anti‐Wrinkle Efficacy |
| Propolis Skin Randomized Trial | 1 2 3 Skin aging is driven by both intrinsic chronological factors and extrinsic environmental insults, particularly oxidative stress from solar radiation and pollution. | 4 | Radić Božo (2026) | Senomorphic Activity of a Novel Standardized Propolis Extract in Human Dermal Fibroblasts: Molecular Insights Into Clinically Proven Anti‐Wrinkle Efficacy |
Source documents