evidence table
Probiotics Stress Randomized Trial Evidence Table
Structured evidence table for Probiotics Stress Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Probiotics Stress Randomized Trial | BMI CBC CFU CRP ESR GPx HC MDA MLR NLR RDW‐SD TAC TOS WC 2024 2024 2015 2021 2021 2020 2017 2021 2018 2024 2021 Undernutrition, characterized by insufficient energy and nutrient intake, affects approximately 390 million adults globally, leading to underweight status, wasting, and increased morbidity (Hegazi et al. ; World Health Organization ). | 2 | Ahmadi‐Khorram Maryam (2026) | A Novel Combination of Probiotic Supplements Reduces Gut Permeability, Oxidative Stress, and Inflammation in Undernourished Adults: A Randomized Controlled Trial |
| Probiotics Stress Randomized Trial | Specifically,has been shown to improve gut permeability,supports mucosal immunity and reduce inflammation, andwas found to promote weight gain in malnourished populations (Gauffin et al. ; Million et al. ; Pan et al. ; Vendt et al. ). | 2 | Ahmadi‐Khorram Maryam (2026) | A Novel Combination of Probiotic Supplements Reduces Gut Permeability, Oxidative Stress, and Inflammation in Undernourished Adults: A Randomized Controlled Trial |
| Probiotics Stress Randomized Trial | However, evidence on the efficacy of specific probiotic strains in enhancing gut barrier function are conflicting, with some studies reporting moderate improvements in tight junction integrity and others depicting minimal impact, due to strain‐specific effects or differences in study design (Al‐Sadi et al. ). | 2 | Ahmadi‐Khorram Maryam (2026) | A Novel Combination of Probiotic Supplements Reduces Gut Permeability, Oxidative Stress, and Inflammation in Undernourished Adults: A Randomized Controlled Trial |
| Probiotics Stress Randomized Trial | Undernutrition disrupts gut microbiota, compromises intestinal barrier function, and promotes systemic inflammation and oxidative stress, which impair nutrient absorption and exacerbate health complications (Genton et al. ; Purnasari et al. ; Thompson et al. ). | 2 | Ahmadi‐Khorram Maryam (2026) | A Novel Combination of Probiotic Supplements Reduces Gut Permeability, Oxidative Stress, and Inflammation in Undernourished Adults: A Randomized Controlled Trial |
| Probiotics Stress Randomized Trial | Metabolic dysfunction-associated steatotic liver disease (MASLD) has replaced older exclusion-based terminology as the preferred term for steatotic liver disease associated with cardiometabolic risk factors. | 4 | Mustika S (2026) | Metabolic Dysfunction-Associated Steatotic Liver Disease: An Update Narrative Review of the Therapeutic Potential of Combining Probiotics and Metformin. |
| Probiotics Stress Randomized Trial | MASLD is now among the most common causes of chronic liver disease and may progress from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH), fibrosis, cirrhosis, and hepatocellular carcinoma. | 4 | Mustika S (2026) | Metabolic Dysfunction-Associated Steatotic Liver Disease: An Update Narrative Review of the Therapeutic Potential of Combining Probiotics and Metformin. |
| Probiotics Stress Randomized Trial | This updated rigorous narrative review synthesizes current evidence on MASLD diagnosis and management, with emphasis on the gut-liver axis and the therapeutic potential of combining probiotics with metformin. | 4 | Mustika S (2026) | Metabolic Dysfunction-Associated Steatotic Liver Disease: An Update Narrative Review of the Therapeutic Potential of Combining Probiotics and Metformin. |
Source documents
- A Novel Combination of Probiotic Supplements Reduces Gut Permeability, Oxidative Stress, and Inflammation in Undernourished Adults: A Randomized Controlled Trial
- Metabolic Dysfunction-Associated Steatotic Liver Disease: An Update Narrative Review of the Therapeutic Potential of Combining Probiotics and Metformin.