Structured evidence table for Probiotics Gum Health Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Probiotics Gum Health Randomized Trial | Standard therapy often relies on antibiotics, but the long-term use has increased antibiotic resistance, including in Indonesia. | 2 | Lestari K (2026) | Oral probiotics and topical secretome to enhance clinical outcomes and microbiome restoration in acne vulgaris: a double-blind, randomised controlled trial protocol. |
| Probiotics Gum Health Randomized Trial | Background Acne vulgaris is a chronic inflammatory condition primarily caused by Cutibacterium acnes , which disrupts skin homeostasis, thereby triggering immune responses and sebum metabolism. | 2 | Lestari K (2026) | Oral probiotics and topical secretome to enhance clinical outcomes and microbiome restoration in acne vulgaris: a double-blind, randomised controlled trial protocol. |
| Probiotics Gum Health Randomized Trial | Dysbiosis is an imbalance in the skin and gut microbiota identified as a significant factor contributing to acne progression. | 2 | Lestari K (2026) | Oral probiotics and topical secretome to enhance clinical outcomes and microbiome restoration in acne vulgaris: a double-blind, randomised controlled trial protocol. |
| Probiotics Gum Health Randomized Trial | Chewing gum is an attractive delivery matrix for oral probiotics because it enables prolonged mechanical dispersion and salivary mixing, facilitates contact with tooth surfaces and interdental niches, and is associated with high patient acceptability and compliance []. | 2 | Cirio Silvia (2026) | Assessing the Impact of Heyndrickxia coagulans Administered Through Sugar-Free Chewing Gum on Dental Biofilm: A Double-Blind Randomized Controlled Trial |
| Probiotics Gum Health Randomized Trial | Clinical evidence supports strain-specific benefits offor gastrointestinal benefits, and emerging preclinical and clinical data suggest that some strains can modulate microbial communities and host responses in ways potentially relevant to oral health. | 2 | Cirio Silvia (2026) | Assessing the Impact of Heyndrickxia coagulans Administered Through Sugar-Free Chewing Gum on Dental Biofilm: A Double-Blind Randomized Controlled Trial |
| Probiotics Gum Health Randomized Trial | However, strain-level characterization, genomic safety screening, and context-specific evidence (particularly for oral delivery) remain important prerequisites for clinical translation [,,]. | 2 | Cirio Silvia (2026) | Assessing the Impact of Heyndrickxia coagulans Administered Through Sugar-Free Chewing Gum on Dental Biofilm: A Double-Blind Randomized Controlled Trial |
| Probiotics Gum Health Randomized Trial | 1 2 The human oral cavity hosts a diverse, site-specific microbial community, including bacteria, fungi, viruses, and archaea. | 2 | Cirio Silvia (2026) | Assessing the Impact of Heyndrickxia coagulans Administered Through Sugar-Free Chewing Gum on Dental Biofilm: A Double-Blind Randomized Controlled Trial |
Source documents