Structured evidence table for Probiotics Anxiety Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Probiotics Anxiety Randomized Trial | It is estimated that fibromyalgia can result in up to approximately 36 000$ of annual direct costs per patient in the US, imposing a considerable burden on the health care systems. | 1 | Nakhostin-Ansari Amin (2026) | Effects of probiotics on psychological issues in people with fibromyalgia: a systematic review |
| Probiotics Anxiety Randomized Trial | The presence of these comorbid medical conditions can make the diagnosis of fibromyalgia challenging, which could lead to mismanagement, overtreatment, and increased drug side effects. | 1 | Nakhostin-Ansari Amin (2026) | Effects of probiotics on psychological issues in people with fibromyalgia: a systematic review |
| Probiotics Anxiety Randomized Trial | Therefore, proper diagnosis of fibromyalgia and its associated comorbidities is crucial for effective management of the conditions. | 1 | Nakhostin-Ansari Amin (2026) | Effects of probiotics on psychological issues in people with fibromyalgia: a systematic review |
| Probiotics Anxiety Randomized Trial | 1 2 [,] 3 [] 4 [] 5 6 [,] 7 8 [,] 7 8 [,] 5 [] Fibromyalgia is a syndrome characterized by chronic widespread musculoskeletal pain, often accompanied by a range of other symptoms, including sleep disturbances, excessive fatigue, and psychological issues such as depression. | 1 | Nakhostin-Ansari Amin (2026) | Effects of probiotics on psychological issues in people with fibromyalgia: a systematic review |
| Probiotics Anxiety Randomized Trial | Conclusion In this randomized, double‑blind, placebo‑controlled pilot trial, both probiotic and placebo groups showed significant improvements in depressive and anxiety symptoms over time, with no significant between‑group differences. | 2 | Mosavat SH (2026) | Effect of probiotic supplement on improvement of depressive symptoms in patients with substance-induced depressive disorder: a randomized, double-blind, placebo-controlled clinical trial. |
| Probiotics Anxiety Randomized Trial | Probiotic supplementation was associated with non‑significant trends in selected inflammatory markers, suggesting possible immunological effects that warrant further investigation. | 2 | Mosavat SH (2026) | Effect of probiotic supplement on improvement of depressive symptoms in patients with substance-induced depressive disorder: a randomized, double-blind, placebo-controlled clinical trial. |
| Probiotics Anxiety Randomized Trial | Background Substance-Induced Depressive Disorder (SIDD) accounts for a high health burden and requires new therapies. | 2 | Mosavat SH (2026) | Effect of probiotic supplement on improvement of depressive symptoms in patients with substance-induced depressive disorder: a randomized, double-blind, placebo-controlled clinical trial. |
| Probiotics Anxiety Randomized Trial | Bidirectional communications between the gut and the brain mediated by the microbiota point to a possible influence of probiotics as a tool for preserving mental health. | 2 | Mosavat SH (2026) | Effect of probiotic supplement on improvement of depressive symptoms in patients with substance-induced depressive disorder: a randomized, double-blind, placebo-controlled clinical trial. |
Source documents